# Project VI: Imaging genetics in SRD: Mega- and Meta-analyses

> **NIH NIH P50** · FLORIDA STATE UNIVERSITY · 2020 · $216,695

## Abstract

ABSTRACT
 Project 6
Project VI of the Florida LDRC, titled Imaging genetics in SRD: Mega- and meta-analyses, is designed in
response to the RFA-HD-17-006's stipulation to obtain converging evidence through the utilization of multiple
methodologies—neuroimaging and genetic in the case of Project VI—in order to both discover and highlight
the most robust and replicable facets of the genome-brain connection in Specific Reading Disabilities (SRD).
Project VI is contextualized by the overall premise of the P50 to reflect on the status of science in the field of
learning disabilities (LD) in general and SRD in particular and, therefore, is framed to generate such a
reflection in the subfield of imaging genetics of SRD. With that in mind, we propose a set of imaging-genetic
meta-analytic studies. Specifically, we are proposing to establish a merged data set that combines behavior,
neuroimaging, and genetic (GWAS) data generated by a group of USA and European investigators. Specific
Aim 1 (SA1) of Project VI is committed to the construction of such a database; it establishes the procedures
for data merging, quality control, deposition, and manipulation. At the time of submission, we have a firm
commitment from contributing investigators to generate a dataset of 1,202 individuals. We have secured three
more tentative commitments that have the potential to substantially increase the dataset. Moreover, we have a
set of additional investigators who have expressed interest, but with whom we have not yet followed up to
appraise the general compatibility of both the brain and genetic data (i.e., the recruitment, collection, and
analyses parameters). SA2 is a continuation and extension of the activities of Project VI over two previous
cycles of funding. This aim will provide an opportunity to interrogate the genetic findings assembled in Project
VI so far for their robustness, replicability, and generalizability using these merged data. Thus, SA2 assures
the continuity of the work carried out by Project VI throughout the two generations of the Florida LDRC. In
contrast, SA3 is exploratory and innovative, both to the field of SRD and to Project VI. It proposes a reversed
GWAS (or set of GWASes) that capitalizes on the availability of multiple neuroimaging phenotypes in the large
merged dataset that we will assemble in SA1. Importantly, to maintain the spirit and the scope of the proposed
work, we will utilize behavioral data only for the purpose of grouping or controlling for level of performance in
SA2 and SA3. In summary, this iteration of Project VI corresponds to the general theme of the third-generation
Florida LDRC: it capitalizes on its own trajectory developed throughout the two previous cycles of funding,
proposes a set of mega- and meta-analytic studies, and creates an opportunity to utilize and further develop a
curated communal resource that has the potential to become a platform for reproducibility tests in the field of
SRD.

## Key facts

- **NIH application ID:** 10003055
- **Project number:** 5P50HD052120-14
- **Recipient organization:** FLORIDA STATE UNIVERSITY
- **Principal Investigator:** ELENA L GRIGORENKO
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $216,695
- **Award type:** 5
- **Project period:** 2006-07-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003055

## Citation

> US National Institutes of Health, RePORTER application 10003055, Project VI: Imaging genetics in SRD: Mega- and Meta-analyses (5P50HD052120-14). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10003055. Licensed CC0.

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