# 3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA)

> **NIH NIH U01** · UNIVERSITY OF WASHINGTON · 2020 · $669,602

## Abstract

ABSTRACT
Alcohol misuse is prevalent among persons living with HIV (PLWH) and associated with
poor outcomes including less engagement in HIV care, more severe liver disease, and
increased age-related comorbidities. Prior research on the intersection of alcohol and
HIV has been conducted in relatively small samples or in select groups whose results
may not be generalizable to the overall population of PLWH. The Alcohol Research
Consortium in HIV–Epidemiology Research Arm (ARCH-ERA) was formed to investigate
short and long-term effects of alcohol on clinical outcomes in the CFAR Network of
Integrated Clinical Systems (CNICS). CNICS is an 8-site national network that is large,
geographically and racially diverse, gender representative cohort of >31,000 PLWH in
care. Careful outcomes adjudication, a large diverse population, and systematic
longitudinal assessments of patient reported alcohol use, drug use, mental health
symptoms, adherence, cognition, and other outcomes enables a rigorous approach to
key questions on HIV and alcohol that are highly responsive to NIH HIV priorities: 1)
disparities in HIV treatment outcomes; 2) HIV-associated comorbidities, neurological
complications and aging. Capitalizing on the resources and infrastructure of CNICS, we
propose the following aims: To examine longitudinal relationships of alcohol use, co-
morbid drug use, and mental health disorders on the HIV Care Continuum; to determine
longitudinal relationships between alcohol and liver disease progression in the era of
direct acting antiretrovirals for hepatitis C virus treatment on liver disease outcomes; and
to determine the impact of alcohol use on age-related comorbidities among PLWH in
care. ARCH-ERA will continue to generate new knowledge on the intersection of HIV
and alcohol to inform future research and clinical care in the US and globally.

## Key facts

- **NIH application ID:** 10003124
- **Project number:** 5U01AA020793-10
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Heidi M. Crane
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $669,602
- **Award type:** 5
- **Project period:** 2011-09-20 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003124

## Citation

> US National Institutes of Health, RePORTER application 10003124, 3/4 Alcohol Research Consortium in HIV - Epidemiological Research Arm (ARCH-ERA) (5U01AA020793-10). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10003124. Licensed CC0.

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