# CSHL Cancer Gene Discovery and Cancer Biology Postdoctoral Research Training Program

> **NIH NIH T32** · COLD SPRING HARBOR LABORATORY · 2020 · $214,339

## Abstract

Project Summary
The objective of the Cancer Gene Discovery and Cancer Biology Postdoctoral Research Training Program at
Cold Spring Harbor Laboratory (CSHL) is to prepare the next generation of cancer biologists to pursue
independent research careers integrating cancer gene discovery with functional biology in order to facilitate
the development and application of novel cancer therapeutic, diagnostic and/or preventive strategies.
Features of this three-year research training program include: a combination of mandatory and elective
didactic courses and seminars; structured career development guidance; graduate and community-based
teaching options; and research experiences in laboratories integrated within our CSH, NCI designated
Cancer Center.
Cancer research opportunities span highly integrated areas that include; 1) Cancer Genetics - genetic and
epigenetic progression of cancer; cancer diagnostics and experimental technology development
(CRISPR/Cas, single cell analysis); 2) Cancer Gene Regulation and Cell Proliferation - splicing, RNA
biology, replication, nuclear structure, transcription, tumor growth and metastasis; 3) Cancer Signal
Transduction - drug sensitivity and resistance, tumor microenvironment and metastasis, immune response;
and 4) Quantitative Biology- population genetics, genome structure and evolution.
Postdoctoral trainees benefit from: a strong faculty to trainee ratio; a collaborative and multidisciplinary
research environment; an internal Executive Committee that includes trainee representatives and an
independent External Advisory Board; an on-site internationally renowned Scientific Meetings and Courses
program; newly expanded state-of-the-art cancer research facilities; enhanced exposure to translational
oncology as part of a new institutional partnership with Northwell Health.
Over the past five years, approximately seventy-four trainees benefited from the program, of which seven
trainees (three per year) were supported by the NCI T32 award, with two additional trainees being supported
by combined New York State matching and CSHL institutional funding. CSHL submitted a competing T32
renewal application in 2015 requesting four positions that fell short of securing renewed NCI funding.
Reviewers found the program's overall impact to be high, but noted several points and recommendations. All
suggestions have been carefully evaluated and addressed in this resubmission. Program enhancements
include: providing trainees with additional opportunities to understand the clinical impact of cancer and to
gain an appreciation of the complexities involved in conducting and participating in clinical research; T32
trainee specific events that include training in Communicating Science to the Public; and gaining knowledge
about the importance of population diversity in cancer health disparities research. Elective courses have
been updated and new approaches to further enhance the diversity of program applicants and participants
have begun.

## Key facts

- **NIH application ID:** 10003139
- **Project number:** 5T32CA148056-10
- **Recipient organization:** COLD SPRING HARBOR LABORATORY
- **Principal Investigator:** Lloyd C Trotman
- **Activity code:** T32 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $214,339
- **Award type:** 5
- **Project period:** 2011-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003139

## Citation

> US National Institutes of Health, RePORTER application 10003139, CSHL Cancer Gene Discovery and Cancer Biology Postdoctoral Research Training Program (5T32CA148056-10). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10003139. Licensed CC0.

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