# Shared Resource Core

> **NIH NIH U54** · DANA-FARBER CANCER INST · 2020 · $217,744

## Abstract

Summary: Proper study design, data generation, and analysis of complex datasets drawn from population-
and molecular-level studies are crucial for the advancement of population and basic science research. To
facilitate this, the Partnership proposes to provide the necessary infrastructure for these activities through the
Research Design and Analysis Core (RDAC) and the Genomics Core (GC), collectively described as the
Shared Resource Core (SRC). The RDAC aims to 1) support quantitative activities involving collection of
original data at different levels – from individuals/patients to organizations and communities; 2) provide training
in the design, implementation and analysis of population science research to U54 participants and members of
the UMass Boston and DF/HCC communities at all academic levels; 3) assist with appropriate experimental
design and statistical analysis of data acquired from laboratory- or clinically-based studies; and 4) serve as a
catalyst for new collaborations between investigators at UMass Boston and DF/HCC partner sites. The RDAC
builds upon and synergizes existing Centers/Cores at UMass Boston and DF/HCC. Similarly, the Partnership
has created the Genomics Core by leveraging genomics services offered by the newly created Center for
Personalized Cancer Therapy (CPCT) at UMass Boston. The GC uses state-of-the-art instrumentation and
data analysis methodologies and aims to provide U54 partners and investigators with accessible research
support platforms to facilitate high-impact genomics-based translational cancer research and basic science
research. Together, the RDAC and GC Shared Resource Core constitutes the framework to provide population
and genomics-based basic science studies with proper study design, data acquisition, and data analysis
across a broad spectrum of 'Cells to Society' research. The SRC will be utilized by all proposed research
projects in this application (see Pilot and Full Project sections). Specifically, the Schrag/Lindsay population
science project will utilize the RDAC to provide consultation in survey development and oversight of necessary
pretesting of English and Spanish-language survey measures, database development, data entry and data
analysis. Dr. Lindsay and the RDAC will work together to provide U54 trainees with intensive training in focus
group procedures, e.g., creation of an interview guide, focus group moderation and qualitative analysis, and
qualitative data coding. The RDAC will also be utilized by the Kulkarni/Zarringhalam/Pandolfi basic science
project to provide assistance with quantitation and statistical analysis of the isogenic WT and DICER mutant
HCT116 carcinoma cell studies and siRNA-mediated ceRNA knock-down studies. The GC will be utilized by
the Siegfried/Sweeney/Van Allen basic science project to generate sequencing data and provide bioinformatics
analysis of sequencing data to call somatic point mutations, short insertion/deletions, and copy number
changes from the ...

## Key facts

- **NIH application ID:** 10003166
- **Project number:** 5U54CA156732-10
- **Recipient organization:** DANA-FARBER CANCER INST
- **Principal Investigator:** WENDY Beth LONDON
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $217,744
- **Award type:** 5
- **Project period:** 2010-09-27 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003166

## Citation

> US National Institutes of Health, RePORTER application 10003166, Shared Resource Core (5U54CA156732-10). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10003166. Licensed CC0.

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