# Human Epilepsy Tools Core (HETC)

> **NIH NIH U54** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $386,278

## Abstract

HUMAN EPILEPSY TOOLS CORE (HETC)
 Both human embryonic stem cells (hESCs) and human induced pluripotent stem cells
(hIPSCs) represent important models for human disorders of the nervous system. Dr. Michael
Uhler will serve as the Director and Dr. Jack Parent will serve as the Co-Director of the HETC
which is housed within the UM Neurology Department. The HETC will provide support to the
three projects of the EpiMVP by providing stem cell models and differentiation methods for the
characterization of epilepsy genes and their variants of unknown significant (VUS). Specifically,
the HETC will provide validated heterozygous and homozygous hESC mutant lines for these
genes as well as doxycycline-inducible transgenic lines that express the wildtype and VUS for
each gene. In addition, the HETC will derive patient iPSC lines for the genes from either
fibroblasts or blood. Finally, the HETC will standardize and optimize both 2D and 3D neuronal
differentiation protocols for use by the investigators in Projects 1 and 2. Thus, the HETC will
serve as a central repository and resource for human stem cell derivation while providing
significant economy as well as quality control for stem cell work within the two projects.

## Key facts

- **NIH application ID:** 10003685
- **Project number:** 1U54NS117170-01
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** MICHAEL D UHLER
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $386,278
- **Award type:** 1
- **Project period:** 2020-09-15 → 2025-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003685

## Citation

> US National Institutes of Health, RePORTER application 10003685, Human Epilepsy Tools Core (HETC) (1U54NS117170-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10003685. Licensed CC0.

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