# 4/6 COMpAAAS U01: Operations Research Study

> **NIH NIH U01** · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · 2020 · $197,206

## Abstract

Project Summary/Abstract
Many persons with HIV have Hepatitis C (HCV) co-infection and consume alcohol. Now that
highly effective and easily tolerated therapies for HCV are available, singular opportunities exist
to prevent downstream morbidity and mortality from HCV including liver failure and
hepatocellular carcinoma (HCC). However, alcohol consumption may offset those benefits as it
magnifies damage from HCV infection, potentially leading to liver inflammation, increased risk of
liver failure, and HCC. Persons with HIV are at particularly high risk of the adverse effects of
alcohol consumption because they already sustain multiple sources of hepatic injury, such as
steatosis and hepatotoxic medications. Moreover, the high cost of HCV therapies and enormous
burden on health expenditures magnifies the importance of employing these treatments
successfully and with favorable value.
In order to weigh these tradeoffs systematically and to inform future HCV treatment guidelines
for individuals with HIV, we seek to employ a decision analytic model to compare alternative
strategies for linking alcohol consumption criteria to HCV treatment eligibility.

## Key facts

- **NIH application ID:** 10003910
- **Project number:** 5U01AA020799-10
- **Recipient organization:** NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- **Principal Investigator:** Ronald Scott Braithwaite
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $197,206
- **Award type:** 5
- **Project period:** 2011-09-06 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10003910

## Citation

> US National Institutes of Health, RePORTER application 10003910, 4/6 COMpAAAS U01: Operations Research Study (5U01AA020799-10). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10003910. Licensed CC0.

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