# Treatment Modifications, Outcomes and Provider Decision Making in the Management of Subsequent Breast Cancers Among Survivors of Childhood Cancer

> **NIH NIH K08** · UNIVERSITY OF MINNESOTA · 2020 · $178,114

## Abstract

Project Summary
Survivors of childhood cancers face multiple late effects of their initial cancer therapy. One of the most difficult
and consequential is the occurrence of a subsequent neoplasm. Subsequent breast cancers are the second
most frequently observed subsequent neoplasm, exceeded only by non-melanoma skin cancers. Although
much attention has been given to subsequent breast cancer risk and risk factors among survivors, there are
limited data on treatment, treatment-related toxicities, survival and physician decision making for these
challenging subsequent neoplasms. Survivors of childhood cancer have previously been exposed to therapies,
including radiation and/or anthracycline chemotherapies, which may limit their ability to safely receive
standard-of-care breast cancer therapy. The overall goals of this study will be: 1) to quantify how overall and
event-free survival among long-term survivors of childhood cancer who develop a subsequent breast cancer
compare to a geographically diverse, age-, race and ethnicity-,breast cancer stage-, and treatment era-
matched cohort of women with similar breast cancer characteristics, and how their overall survival compares to
SEER survival estimates; 2) to describe how survivors of childhood cancer who develop a subsequent breast
cancer are medically managed and how treatment compares to a contemporarily-treated, age-, race and
ethnicity-, breast cancer stage-, and treatment era-matched matched comparison cohort and to contemporary
National Comprehensive Cancer Network treatment guidelines, and to describe treatment-related toxicities
among survivors with subsequent breast cancer and compare the toxicity profile with a matched comparison
cohort of women with primary breast cancer; and 3) to describe how breast cancer treatment decisions are
made, through semi-structured interviews and surveys, among medical and radiation oncologists. This project
will provide data necessary to improve health outcomes in this growing high-risk and vulnerable population of
survivors of childhood cancer. Understanding the drivers of decision-making, the way women with subsequent
breast cancers are treated, and how their outcomes compare to other women with breast cancer will guide
educational interventions and the development of treatment guidelines for women with subsequent breast
cancer. The skills developed through the completion of the aims in this proposal, in complex epidemiological
study design, qualitative and mixed methods study methodology, and study leadership, will lay the groundwork
for leading novel and high-impact survivorship studies. This project will serve as a transition point from working
as a mentored physician scientist to an independent investigator, as demonstrated by a planned R01
submission during the final year of this study.

## Key facts

- **NIH application ID:** 10004603
- **Project number:** 5K08CA234232-03
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** Lucie Marie Turcotte
- **Activity code:** K08 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $178,114
- **Award type:** 5
- **Project period:** 2018-09-17 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10004603

## Citation

> US National Institutes of Health, RePORTER application 10004603, Treatment Modifications, Outcomes and Provider Decision Making in the Management of Subsequent Breast Cancers Among Survivors of Childhood Cancer (5K08CA234232-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10004603. Licensed CC0.

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