# Waisman Intellectual and Developmental Disabilities Research Center

> **NIH NIH U54** · UNIVERSITY OF WISCONSIN-MADISON · 2020 · $1,101,600

## Abstract

We seek continued support of the Waisman Center Intellectual and Developmental Disabilities Research
Center, a comprehensive interdisciplinary program focused on IDD spanning the biological, biobehavioral, and
bio-behavioral sciences. The Waisman IDDRC brings together 46 PIs from 21 academic departments from the
UW-Madison's Schools of Medicine and Public Health, Veterinary Medicine, Pharmacy, Agriculture and Life
Sciences, Letters and Science, Education, Engineering, and Human Ecology. This application requests
support for an Administrative Core (Core A), providing scientific leadership, program and faculty development,
facilitation of interdisciplinary collaboration, and biostatistical and bioinformatics expertise; and three innovative
scientific core services: Clinical Translational (Core B), providing services, resources, and training in the
recruitment of human participants, clinical assessment, behavioral methods development, and cGMP
biomanufacturing of therapeutics; Brain Imaging (Core C), providing access to state-of-the-art neuroimaging
instrumentation (3T MRI, PET, and microPET scanners for human, non-human primate, and rodent scanning,
and an EEG recording system), as well as expertise and tools for image acquisition and analysis; and IDD
Models (Core D), providing resources, expertise, and technical services in the generation and characterization
of mutant or genetically engineered strains of mice and rats, the generation of induced pluripotent stem cell
lines from humans with IDD conditions, and facilities for phenotypic characterization of these models using
molecular, cellular and behavioral technologies. In addition, we request support for a Research Project that is
focused on the impact of variations in CGG repeat length in the FMR1 gene on health and function at the
cellular through organismal level, using both cell culture models and human subjects.
We propose to provide core support to 79 research projects headed by 46 PIs addressing three broad themes
relevant to IDD: 1) nervous system development and pathogenesis, 2) IDD conditions, and 3) assessment,
interventions, and therapeutics. Collectively the core services and the research project of the Waisman Center
IDDRC will stimulate new interdisciplinary IDD research and enhance existing IDD investigations sharpening
our focus on discovery, prevention, and treatment for IDD conditions, and improvement of the quality of life of
individuals with IDD and their families.

## Key facts

- **NIH application ID:** 10005046
- **Project number:** 5U54HD090256-05
- **Recipient organization:** UNIVERSITY OF WISCONSIN-MADISON
- **Principal Investigator:** Qiang Chang
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,101,600
- **Award type:** 5
- **Project period:** 2016-09-22 → 2021-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005046

## Citation

> US National Institutes of Health, RePORTER application 10005046, Waisman Intellectual and Developmental Disabilities Research Center (5U54HD090256-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10005046. Licensed CC0.

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