# Administrative Core

> **NIH NIH P50** · CASE WESTERN RESERVE UNIVERSITY · 2020 · $333,449

## Abstract

The mission of the CORT is to advance therapy for psoriasis and related comorbidities by leveraging new
bioinformatic methodologies with well-developed murine and human experimentation capabilities. This
technology concatenation is expected to more nimbly translate new scientific opportunities into clinical
applications. The CORT Administrative Core (AC) proposes to manage an innovative model wherein a
collaborative research project (CRP) will serve as the central hub that will iterate significant bi-directional
work from 2 highly interactive research cores to experimentally test hypotheses and newly identified
pathway specific and repurposed FDA drug leads. The AC will accomplish this goal through its Aims to: 1.
Convene an Internal Advisory Committee and an External Advisory Board which a) develops and applies
accountability metrics for the CRP, each Core, and the P&F projects, b) manages a Go-NoGo iterative
algorithmic decision-making process regarding CORT resource utilization and c) coordinates patient cohort
assets and regulatory compliance; 2. Provide fiscal management of the CORT; 3. Branch out exciting new
developments deriving from CORT findings through a robust Pilot & Feasibility (P&F) program; 4. Organize
and advertise Enrichment Activities that bring CORT and Community researchers together in scientific venues
to exchange ideas and new technologies.
 The AC leadership will work closely not only with lab scientists, but also with the leadership and
programmers of the CLEveland Area Research Platform for Advancing Translational Healthcare
(CLEARPATH), a comprehensive research database with Limited Data Set contribution from all 3 major
Cleveland healthcare systems. CLEARPATH will create connected data (e.g., Biospecimen results, EMR
clinical phenotype, `Omics data) as well as a Single person record across the system, enabling research cohort
discovery and validation across the aggregate dataset. This approach will allow us to preliminarily validate
psoriasis cohort subsets, mix `omic pathways and drug leads identified by the Cores and CRP. In addition to
its roles as an information conduit and facilitator for research, the AC also promotes the cutaneous research
environment for psoriasis and its comorbid and related conditions through enrichment programs. As such, the
AC is instrumental in the design and planning of research symposia, and recruiting potential P&F program
recipients with innovative technologies and/or complementary research expertise to the CORT.
 The cross-disciplinary approach of combining a Preclinical Modeling Core (PMC) with an Applied Meta
`Omics Core (AMC) that takes advantage of artificial intelligence, data mining, network techniques and
machine learning to query available interaction networks and highly annotated integrated electronic medical
records (EMRi) is highly innovative. The active engagement of the AC will be instrumental for the successful
achievement of the broader goal of identifying new psoriasis...

## Key facts

- **NIH application ID:** 10005118
- **Project number:** 5P50AR070590-04
- **Recipient organization:** CASE WESTERN RESERVE UNIVERSITY
- **Principal Investigator:** Kevin D Cooper
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $333,449
- **Award type:** 5
- **Project period:** 2017-09-20 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005118

## Citation

> US National Institutes of Health, RePORTER application 10005118, Administrative Core (5P50AR070590-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10005118. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*