# Biospecimen and Pathology

> **NIH NIH P50** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $258,761

## Abstract

PROJECT SUMMARY (Biospecimen and Pathology Core) 
The translational research proposed in the MD Anderson Cancer Center Prostate Cancer SPORE requires a 
broad range of comprehensive support. The Biospecimen and Pathology Core supports investigators by 
providing (1) a biospecimen resource with clinically and pathologically annotated biospecimens that 
encompass the clinical spectrum of prostate cancer; (2) clinically relevant patient-derived xenografts reflective 
of the clinical challenges addressed in the projects; (3) clinical and laboratory personnel experienced in the 
conduct, collection, and processing of specimens from clinical trials; and (4) dedicated pathologists and 
clinicians with technical expertise who will conduct and interpret tissue-based studies and coordinate all core 
activities. To maximize analyses using small samples and enhance collaboration among investigators at MD 
Anderson and other institutions, Core personnel will prepare and distribute tissue derivatives linked with 
specific disease states. Close collaboration with investigators and electronic processing of requests for 
biospecimens and clinical information by the Tissue Acquisition and Distribution Committee will ensure the 
evolving needs of each project will be met in a timely manner. In addition, the Core’s Prometheus informatics 
staff will manage the repository for clinical and translational data so that investigators will have the full power of 
detailed, well-curated clinical annotations essential to maximizing the information gained from often small 
samples. The Prometheus system also facilitates the interpretation of analyses within specific clinical and 
biologic contexts and enhances interactions among projects. Other functions of Prometheus are to ensure 
common data format and ontologic term usage, data integrity, audit history, and data security. Prometheus will 
also facilitate future data exchanges with investigators and SPOREs at other institutions. Finally, Prometheus 
will enable all statistical analyses performed in the Biostatistics and Bioinformatics Core to be carried out using 
the most up-to-date clinical and translational data.

## Key facts

- **NIH application ID:** 10005146
- **Project number:** 5P50CA140388-10
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Patricia Troncoso
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $258,761
- **Award type:** 5
- **Project period:** 2009-09-02 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005146

## Citation

> US National Institutes of Health, RePORTER application 10005146, Biospecimen and Pathology (5P50CA140388-10). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10005146. Licensed CC0.

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