# Core A: Administration

> **NIH NIH P01** · UNIVERSITY OF PENNSYLVANIA · 2021 · $67,675

## Abstract

SUMMARY
The Administrative Core A of this Program Project is designed to provide scientific leadership, effective
communication and an administrative support structure to ensure the coordination of all Program
Project activities. In 2015, the four PIs of this multiple PI P01 proposal reported in Nature that
hypofractionated radiation and dual checkpoint blockade activated anti-tumor T cell immunity in both
mice and patients via non-redundant mechanisms, explaining the apparent synergy. This newly
proposed Program Project seeks to deeply extend our knowledge regarding the intersection of radiation
and immunotherapy of cancer. The proposed program has three projects and three cores, with a
balance of senior leaders in multiple disciplines working alongside more junior faculty investigators as a
team. We have taken advantage of the large and efficient administrative staff and the centralized
research organizations at the Abramson Cancer Center (ACC) of the University of Pennsylvania to
achieve our objectives. Strong institutional commitment from the ACC and Penn has helped lay the
foundation for our scientific and translational achievements. The essential services provided by the
Core A include: administrative support for all of the investigators in each project and core; fiscal
management and oversight for all components of the Program Project; and organization and
communication of all Program Project meetings and activities. The overall goal of this Core is effective
and efficient leadership of the P01. The roles of the Core Director, Co-Director and administrative staff
are to facilitate communication while stimulating scientific and technological interactions. In order to
achieve this goal, the Core has established three objectives: (1) Establish and maintain an
administrative structure to provide support for and management of all Program Project activities, (2)
Foster an environment to maximize collaborative research among Program Project investigators and
between other P01 and NCI initiatives, and (3) Ensure compliance with all institutional, governmental
and NCI regulations and policies.

## Key facts

- **NIH application ID:** 10005186
- **Project number:** 5P01CA210944-04
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Robert H. Vonderheide
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $67,675
- **Award type:** 5
- **Project period:** 2017-08-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005186

## Citation

> US National Institutes of Health, RePORTER application 10005186, Core A: Administration (5P01CA210944-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10005186. Licensed CC0.

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