# Core 1: Pathology Core

> **NIH NIH P50** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $219,678

## Abstract

Core 1: Pathology SUMMARY/ ABSTRACT 
The individual research projects comprising this Ovarian Cancer SPORE application require the procurement, 
processing, and analysis of histopathological material from patients with ovarian cancer and benign ovarian 
diseases. The research projects have needs for frozen and formalin-fixed, paraffin-embedded samples of 
tumor and normal tissue. The proposed Pathology Core augments the already established MD Anderson 
Cancer Center Gynecological Tumor Bank and the P30-sponsored MD Anderson Cancer Center Centralized 
Tissue Repository with supporting database and intranet access. The Core provides for tissue acquisition by 
experienced gynecological pathologists to assure high-quality tissues for the investigators participating in this 
SPORE as well as investigators of other SPOREs. 
The goal of the Pathology Core is to provide frozen tissue, paraffin-embedded tissue, and histopathological 
expertise related to the specific needs of the research projects comprising this SPORE proposal. To achieve 
this goal, the Pathology Core proposes the following Specific Aims: Aim 1 is to maintain a frozen and 
paraffin-embedded tissue repository of ovarian cancer, benign ovarian processes, and normal ovary. The 
primary tissue source will be operative and biopsy specimens submitted to the Department of Pathology at MD 
Anderson Cancer Center. Aim 2 is to provide pathological review for all clinical specimens utilized in the 
SPORE projects and to provide histopathological technical services as necessary. Such technical services 
include immunohistochemistry, in situ hybridization, creation of specific tissue microarray slides, pathological 
evaluation of mouse tumors, and microdissection of tissue sections. Aim 3 is to establish a blood/urine/ascites 
fluid repository from patients undergoing surgery for ovarian cancer and benign ovarian processes. These 
fluids will provide the resources for the testing of putative prognostic and diagnostic markers derived from 
experiments in the SPORE projects. Aim 4 is to create and maintain a relational SPORE Database for all 
samples collected by the Pathology Core. This SPORE Database will provide for a virtual tissue repository that 
can be shared electronically with all SPORE investigators.

## Key facts

- **NIH application ID:** 10005290
- **Project number:** 5P50CA217685-04
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** JINSONG LIU
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $219,678
- **Award type:** 5
- **Project period:** 2017-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005290

## Citation

> US National Institutes of Health, RePORTER application 10005290, Core 1: Pathology Core (5P50CA217685-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10005290. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*