# Effects of insulin on NAc excitatory transmission and motivation for food

> **NIH NIH R01** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $386,503

## Abstract

ABSTRACT: It is well-established that actions of insulin in the brain affect feeding. However, very little is
known about the underlying mechanisms (see Fernandez and Torres-Aleman, 2012 for review). A handful of
studies suggest that insulin modulates the function of brain reward and motivation systems that are involved in
food-seeking and feeding behavior such as the nucleus accumbens (NAc). For example, activation of insulin
receptors enhances dopamine release in the NAc and decreases food intake when infused into the NAc
(Stouffer et al, 2015; Figlewicz et al, 2006). In addition, one study has shown that insulin reduces excitatory
transmission in the VTA and a few studies in younger animals have found that insulin modulates AMPA
receptor (AMPAR) synaptic trafficking in cortical neurons (Beattie et al, 1995; Labouebe et al, 2013; Liu et al,
2013). Excitatory transmission via AMPARs in the NAc increases motivation for food (Di Ciano et al, 2001).
However, the effect of insulin on NAc excitatory transmission or food-seeking is unknown. Our long-term goal
is to understand how NAc excitatory transmission and food-seeking behavior are modulated by insulin. Our
preliminary data suggest that insulin receptor activation increases excitatory transmission in the NAc via
mechanisms involving nitric oxide and enhanced glutamate release, and that diet-induced obesity reduces the
effects of insulin on NAc excitatory transmission. Furthermore, we found that intra-NAc insulin enhanced food-
seeking behaviors in non-obese rats. The main objectives of the proposed studies are to determine the
mechanism by which insulin receptor activation enhances NAc excitatory transmission, and the effect of insulin
receptor activation on food-seeking behavior in non-obese and obese rats. These studies will provide a
fundamental information about the effects of insulin on NAc function and the role of insulin in food-seeking in
the non-obese and obese state.

## Key facts

- **NIH application ID:** 10005346
- **Project number:** 5R01DK115526-03
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Carrie Ferrario
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $386,503
- **Award type:** 5
- **Project period:** 2018-09-05 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005346

## Citation

> US National Institutes of Health, RePORTER application 10005346, Effects of insulin on NAc excitatory transmission and motivation for food (5R01DK115526-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10005346. Licensed CC0.

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