# Developing Heparan Sulfate Glycan Array

> **NIH NIH R44** · GLYCAN THERAPEUTICS CORPORATION · 2020 · $1,443,680

## Abstract

This SBIR phase II proposal is aimed at developing microarray technology to study the
interactions between heparan sulfate (HS) and proteins. HS is a highly sulfated
polysaccharide displaying a wide range of biological functions. There is a strong
demand in the research community for a high throughput method to study the binding
between HS and proteins. During the previously funded phase I study
(R41GM123792), Glycan Therapeutics has developed and launched a pilot HS
microarray service. The outcome from the STTR grant clearly demonstrates that the
research community greatly appreciates a convenient and reliable HS microarray
service. This phase II application is focused on the expansion of the HS microarray
service.
 Aim 1 is designed to expand the HS oligosaccharide library from 95 to 250 structures.
A larger number of HS oligosaccharides on the microarray will enhance its ability to
study the relationship between the function and structure of HS saccharide sequences.
Aim 2 will develop a bioinformatic approach to structurally triage the oligosaccharides
based on microarray data. The bioinformatic method is expected to predict additional
structures that may interact with the target proteins. A streamlined website will simplify
data presentation for end users to acquire the data without technical complexity. Our
success will lead to a convenient and reliable research tool for advancing
glycosciences.

## Key facts

- **NIH application ID:** 10005531
- **Project number:** 2R44GM123792-03
- **Recipient organization:** GLYCAN THERAPEUTICS CORPORATION
- **Principal Investigator:** Guowei Su
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,443,680
- **Award type:** 2
- **Project period:** 2017-09-01 → 2022-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005531

## Citation

> US National Institutes of Health, RePORTER application 10005531, Developing Heparan Sulfate Glycan Array (2R44GM123792-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10005531. Licensed CC0.

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