# Kansas Intellectual and Developmental Disabilities Research Center

> **NIH NIH U54** · UNIVERSITY OF KANSAS LAWRENCE · 2020 · $1,080,000

## Abstract

The Kansas Intellectual and Developmental Disabilities Center (KIDDRC) supports rigorous and high-impact
basic and applied research within themes that are relevant to the etiology, identification, prevention, and
treatment of intellectual and developmental disabilities (IDD). The Center is organized around projects that fall
into four basic themes: (1) Language, Communication Disorders, and Cognition, (2) Risk, Intervention, and
Prevention, (3) The Neurobiology of IDD, and (4) Cellular and Molecular Biology of Early Development. To
achieve its mission, the KIDDRC seeks to develop new interdisciplinary research initiatives relevant to the
Center’s mission by bringing together scientists across the various sites of the Kansas Center as well as
promoting collaboration with researchers at other institutions. It supports existing and new projects with cost-
effective, scientifically generative, state-of-the-art core services, resources, and facilities that directly enhance
the quality, quantity, and impact of science produced by center investigators and their collaborators, and to
provide highly efficient, cost-effective systems for planning, developing, managing, coordinating, and
disseminating research activities associated with the center. The KIDDRC proposes to operate five Cores in
support of its projects. An Administrative Core coordinates and integrates services and functions across the
three physical locations of the KIDDRC in Lawrence and Kansas City and provides scientific leadership and
governance mechanisms to ensure that scientific cores are current and efficiently run. A Clinical Translational
Core provides KIDDRC investigators with several tools for enhancing translational research, addressed
broadly by facilitating contact with individuals with IDD for research. A Preclinical Models Core facilitates
translational applications by assisting in the development of cellular and organismal models of IDD. This is
done by providing infrastructure and resources needed to create and characterize laboratory models of IDD
and by extending KIDDRC’s prior capabilities for analyzing behavior, anatomy, physiology, and gene
expression. This latter goal includes cutting-edge genome editing technologies to aid in generating cellular
models using patient–derived cells. A Clinical Outcomes/Biobehavioral Technology Core provides high-quality,
cost-effective support to KIDDRC research programs requiring quantitative measurement of human
neurobehavioral and behavioral outcomes, as well as biological correlates. The CBC includes tools for the
generating, collecting, automating, and validating such measures. The fifth core is a Research Design and
Analysis Core (RDAC), which supports the analysis of data from both preclinical and clinical research through
state-of-the-art statistical and bioinformatics methods. Finally, a Research Component housed within the
KIDDRC seeks to evaluate the efficacy of multimodal intervention for language in a group of children wit...

## Key facts

- **NIH application ID:** 10005907
- **Project number:** 5U54HD090216-05
- **Recipient organization:** UNIVERSITY OF KANSAS LAWRENCE
- **Principal Investigator:** JOHN A. COLOMBO
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,080,000
- **Award type:** 5
- **Project period:** 2016-09-22 → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005907

## Citation

> US National Institutes of Health, RePORTER application 10005907, Kansas Intellectual and Developmental Disabilities Research Center (5U54HD090216-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10005907. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*