# Preclinical Models Core

> **NIH NIH U54** · UNIVERSITY OF KANSAS LAWRENCE · 2020 · $237,533

## Abstract

The objective of the Preclinical Models Core (PMC) of the Kansas Intellectual and Developmental Disabilities
Research Center (KIDDRC) is to provide integrated core facilities and services that optimally facilitate creation
and analysis of cellular and organismal models of IDD. To accomplish this, the PMC will consolidate and
integrate new and established core technologies and services. This involves extending KIDDRC’s existing
capabilities in analyzing behavior, anatomy, physiology and gene expression, to now include mutant mice
production (established but not directly affiliated with KIDDRC), and establishing new facilities that provide
cutting-edge genome editing technologies to aid in generating cellular models using patient–derived cells.
The PMC builds on the long-standing KIDDRC tradition of providing outstanding core support to its members.
The PMC represents a reconfiguration of key elements of services, and features Rodent Behavioral Facilities
(RBF), which provide behavioral testing for sensory and motor function, cognitive and social behaviors,
memory and learning, and somatic and visceral pain, and services built around microscopy and image
analysis, genomics, and data management support. The PMC also reflects a major new direction by including
resources and technologies for model creation: The Transgenic and Gene Targeting Facility (TGF), will cover a
broad range of mouse and pluripotent stem cell transgenesis and mutagenesis methods. These new
technologies will now have prominent roles in providing the PMC with extensive capabilities for generating
cellular and organismal models of IDD. This core builds on a solid history of providing effective, highly valued
resources and services to KIDDRC programs. The current application advances prior capabilities by
incorporating important new services in model creation and phenotyping. A novel feature is the complete
integration of services to provide a continuous pipeline of core technologies beginning with cellular and rodent
modeling and extending through behavioral assays, metabolic and biomarker phenotyping, cellular and
subcellular analysis, and transcriptional analysis, with ancillary analysis as appropriate. We believe that this
approach will yield well characterized cell and rodent models to facilitate our understanding of IDD and to guide
us in the development of new therapeutic modalities.

## Key facts

- **NIH application ID:** 10005933
- **Project number:** 5U54HD090216-05
- **Recipient organization:** UNIVERSITY OF KANSAS LAWRENCE
- **Principal Investigator:** KENNETH E MC CARSON
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $237,533
- **Award type:** 5
- **Project period:** — → 2023-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10005933

## Citation

> US National Institutes of Health, RePORTER application 10005933, Preclinical Models Core (5U54HD090216-05). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10005933. Licensed CC0.

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