# Preferences for PrEP in Tanzanian Women at Heightened Risk of HIV Infection

> **NIH NIH K01** · JOHNS HOPKINS UNIVERSITY · 2020 · $125,170

## Abstract

Project Summary
The purpose of this Mentored Research Scientist Career Development Award (K01) application is to develop
Dr. Sarah Beckham’s career as an independent investigator in implementation science to optimize evidence-
based HIV interventions in low-income countries, particularly among high-risk women. This K01 will provide the
necessary support to achieve the following goals: 1) to become an expert in implementation science theories
and methods in public health; 2) to gain training in the theory and application of stated-preferences methods,
particularly discrete-choice experiments (DCE); 3) to conduct preference heterogeneity analyses of stated-
preference data using latent class finite-mixtures models; 4) to become an expert in pre-exposure prophylaxis
(PrEP) implementation research, particularly in low-income countries. To support these goals, Dr. Beckham
has a mentoring team of her primary mentor, Dr. Deanna Kerrigan, a specialist in implementation of
community-based HIV interventions for high-risk women; three co-mentors, Dr. John FP Bridges, an expert in
stated-preferences methods; Dr. Chris Beyrer, a leading HIV researcher with expertise in PrEP implementation
for high-risk populations; and Dr. Noya Galai, a biostatistician who applies her skills to the development and
application of methods to public health; and a collaborator, Dr. Jessie Mbwambo, a leading researcher in sub-
Saharan Africa (SSA), specializing in implementing HIV interventions for high-risk populations. Given the high
burden of HIV among female sex workers (FSW), integrating PrEP into HIV services is an urgent priority and
requires implementation science research to identify optimal patient-focused strategies and drug formulations
(e.g. tablet, injectable, cervical ring) that are acceptable to the intended populations and reaffirm their dignity,
rights, and choice. The goal of this study is to measure high-risk women’s preferences for PrEP and explore
healthcare provider-level challenges, to inform future optimal implementation of PrEP into community-based
interventions. To achieve these goals, this study has the following research aims: 1) Quantify high-risk
women’s stated preferences for PrEP through a discrete choice experiment (DCE) comparing key attributes of
PrEP (e.g. formulation, side effects, stigma, access). This aim will embed and analyze a DCE in the parent
project survey. 2) Identify preference heterogeneity across the different attributes of PrEP using a latent class
finite-mixture model to account for differences between groups of respondents (“latent classes”). 3) Identify
barriers and facilitators to healthcare providers’ willingness to prescribe PrEP to high-risk women and develop
a provider readiness tool, using key informant and semi-structured interviews of healthcare providers and
health sector officials and the adaptable Tailored Implementation for Chronic Diseases checklist to guide the
development of the tool. This training and research p...

## Key facts

- **NIH application ID:** 10006040
- **Project number:** 5K01MH114715-04
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Sam Wilson Cole
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $125,170
- **Award type:** 5
- **Project period:** 2017-09-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006040

## Citation

> US National Institutes of Health, RePORTER application 10006040, Preferences for PrEP in Tanzanian Women at Heightened Risk of HIV Infection (5K01MH114715-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10006040. Licensed CC0.

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