# Bioinformatics and Data Management Core

> **NIH NIH U54** · INDIANA UNIVERSITY INDIANAPOLIS · 2020 · $1,407,034

## Abstract

PROJECT SUMMARY BIOINFORMATICS AND DATA MANAGEMENT CORE (BMDC) 
The IU/JAX Alzheimer’s Disease Precision Models Center (ADPMC) Bioinformatics and Data Management 
Core (DBMC) will import, integrate, and analyze external data resources to identify and prioritize candidate 
genes and variants for animal modeling. After model characterization, the DBMC will determine data standards 
to be implemented in an Alzheimer’s Model Data Portal that will house and distribute model data for broad 
community use. The overarching goals of the DBMC are the creation of a bioinformatic pipeline that: identifies 
key Alzheimer’s variants from new genetic resources; shares detailed characterization of the effects of these 
variants in advanced animal models; aligns human disease and animal model phenotypes to specify the 
specific research utility of each model; and disseminates preclinical testing protocols and results. To achieve 
these goals, we have assembled a team of computational researchers with complementary expertise in 
genetics, genomics, and data management. The Core will be led by a team at JAX, which has long been a 
major center for the analysis of mouse genetics and the quantitative characterization of mouse disease 
models. Expertise in the analysis of Alzheimer’s disease neuroimaging data will be contributed by the Indiana 
Alzheimer’s Disease Center. Data warehousing, dissemination, and standards will be provided by Sage 
Bionetworks, a leading portal for Alzheimer’s disease data from AMP-AD and other large-scale resource 
projects.

## Key facts

- **NIH application ID:** 10006151
- **Project number:** 5U54AG054345-05
- **Recipient organization:** INDIANA UNIVERSITY INDIANAPOLIS
- **Principal Investigator:** Gregory W Carter
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,407,034
- **Award type:** 5
- **Project period:** 2016-09-30 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006151

## Citation

> US National Institutes of Health, RePORTER application 10006151, Bioinformatics and Data Management Core (5U54AG054345-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10006151. Licensed CC0.

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