# Biostatistics and Bioinformatics Core

> **NIH NIH P50** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $194,115

## Abstract

Biostatistics and Bioinformatics Core SUMMARY/ABSTRACT
The Biostatistics and Bioinformatics Core for the Endometrial Cancer SPORE program will support the
Projects, and assist the other Cores, in the design and interpretation of clinical and preclinical experiments,
and the acquisition and management of data. Core services will be critical for the clinical trials of the Projects,
and their use of high-dimensional methodologies of gene expression profiling (GEP), next-generation
sequencing (NGS) and Reverse Phase Protein Arrays (RPPAs). The Core will incorporate sound experimental
design principles within each Project, specific to the scientific issues being addressed. Each Project will be
provided with tailored analyses, accompanied by appropriate and sometimes novel biostatistical or
bioinformatics methods. Core leaders will work with Project investigators to identify quantitative measures that
can be used to test study hypotheses, including determining sample sizes to ensure sufficient power for the
studies. The leaders of the Core will confer regularly with Project investigators to discuss the design and
conduct of research projects, evaluate results of analyses, discuss potential new research initiatives and
directions within the SPORE, and promote publication of findings. Interactions between the Core and Projects,
as well as other integration, will be facilitated by a web-accessible database of relevant information generated
by each Project, to be developed and maintained by the Core.
The main objectives of the Biostatistics and Bioinformatics Core are to:
1. Provide biostatistics and bioinformatics expertise in the design and conduct of laboratory experiments and
 clinical trials arising from the research proposed in this application.
2. Provide biostatistics and bioinformatics analysis and interpretation of all data collected under the SPORE
 Projects, Career Enhancement Program Projects, Developmental Projects, and other Cores.
3. Collaborate and assist all project investigators with the publication of scientific results.
4. Develop and maintain a web-accessible, SPORE-specific database of relevant information for all Projects.

## Key facts

- **NIH application ID:** 10006200
- **Project number:** 5P50CA098258-15
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** Ying Yuan
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $194,115
- **Award type:** 5
- **Project period:** 2003-09-01 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006200

## Citation

> US National Institutes of Health, RePORTER application 10006200, Biostatistics and Bioinformatics Core (5P50CA098258-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10006200. Licensed CC0.

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