# Core B - Human Subjects Core

> **NIH NIH P01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $409,165

## Abstract

Summary / Abstract
The Human Subjects Core will provide a core resource for the recruitment of human participants for clinical
studies that support the aims of the projects. Recruiting human subjects for mechanism-oriented clinical research
protocols requires well-developed systems to ensure successful subject recruitment and the collection of high
quality biospecimens from well-characterized human subjects. The Core will serve all projects, and it will provide
strong resources for the safe conduct of human-based research. The clinical studies conducted by the core
involve complicated protocols that include virtual navigational bronchoscopy. The infrastructure required to
support this kind of human research is complex and challenging and the core provides experienced and highly
trained personnel to meet this challenge. Therefore, the first aim of the core is to provide a human subjects core
for PPG investigators with strong personnel resources and effective participant recruitment systems to ensure
the safe conduct of the protocols, compliance with regulatory requirements, and timely recruitment. The second
aim of the core is to enroll human participants in two clinical studies to support the three PPG projects: (i) “Study
Of Focal Airway disease in Asthma using Image Guided Bronchoscopy” - “SOFA study”; this study is notable for
its use of virtual navigational bronchoscopy to allow directed collection of airway biospecimens from mucus
plugged airways and control airways (patent airways); (ii) “Tissue Immune interaction in nasal Polyposis - “TIP
study”. The TIP study is notable for its collection of nasal polyp tissue and sinus mucus samples. Both studies
will provide high quality biospecimens from either lower airway (SOFA study) or upper airway (TIP study) type 2
niches.

## Key facts

- **NIH application ID:** 10006349
- **Project number:** 5P01HL107202-07
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** John V Fahy
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $409,165
- **Award type:** 5
- **Project period:** 2012-08-15 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006349

## Citation

> US National Institutes of Health, RePORTER application 10006349, Core B - Human Subjects Core (5P01HL107202-07). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10006349. Licensed CC0.

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