# Core 2: Pathology and Tissue Core

> **NIH NIH P50** · UNIVERSITY OF TX MD ANDERSON CAN CTR · 2020 · $196,809

## Abstract

Core 2
Specific Aims
The primary objective of the M.D. Anderson Cancer Center (MDACC) Leukemia Spore is to improve the
treatment of patients with leukemia. A fundamental component to meeting this objective is the conduct of focused
translational research involving human tissue and blood specimens, allowing investigation of the biology of target
and normal tissues, evaluation of treatment effects on both target and normal tissues, and modulation of relevant
biomarkers. To these ends, the Leukemia Sample Distribution, Banking and Array Profiling Core (hereafter Core
2), will collect, process and maintain human tissue specimens from patients and will disperse these tissues to
Leukemia Spore investigators. The Core will also provide genome-wide molecular profiling of RNA and protein
expression, which provide insights into cellular physiology such as signaling pathway activity.
The AML Tissue Sample, Distribution, Banking and Array Profiling Core has the following objectives:
1. Develop and maintain a repository of intact cells, serum, DNA, RNA and protein from blood and bone
 marrow specimens obtained from AML patients at MDACC.
 2. Maintain a comprehensive, prospective, interactive online database with detailed clinical and pathologic
 data for the samples received by the Core.
3. Provide Reverse Phase Protein Arrays (RPPA) from AML patient samples for screening of protein
 expression in bulk leukemia cells, leukemia stem cells, and mesenchymal stromal cells (MSC).
 4. Provide RNA-Seq data interpretation for gene expression profiling (GEP).
 5. Facilitate inter- and extra- Leukemia Spore collaborations through sharing of blood and marrow resources.

## Key facts

- **NIH application ID:** 10006809
- **Project number:** 5P50CA100632-18
- **Recipient organization:** UNIVERSITY OF TX MD ANDERSON CAN CTR
- **Principal Investigator:** STEVEN M KORNBLAU
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $196,809
- **Award type:** 5
- **Project period:** 2003-08-05 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006809

## Citation

> US National Institutes of Health, RePORTER application 10006809, Core 2: Pathology and Tissue Core (5P50CA100632-18). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10006809. Licensed CC0.

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