# Data Repository and Management Core

> **NIH NIH U2C** · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2020 · $1,086,551

## Abstract

DATA REPOSITORY AND MANAGEMENT CORE PROJECT SUMMARY
The Data Repository and Management Core (DRMC) will advance scientific understanding of environmental
exposures by expanding our successful CHEAR Data Center (DC) data portal and repository to encompass
humans at all life stages. Our proposed HHEAR DC data portal and repository, along with our effective user
support team, will help researchers add comprehensive exposure analysis to their studies. Our demonstrated
commitment to FAIR principles and our unique harmonized data sets will enhance research productivity and
general public understanding by (1) providing access to cleaned and harmonized data and larger data sets for
greater statistical power and maximal reuse; (2) interoperating with relevant national data sets such as the
Metabolomics Workbench, ECHO, and others to facilitate data submission of new data types; and (3)
facilitating access to modern collaborative data analysis tools such as Jupyter notebooks and Google's
Colaboratory. We will employ best practices for high reliability and security and follow HIPAA guidelines. To
develop effective and focused infrastructure, services, and processes tailored for the CHEAR community, our
interdisciplinary team developed strong partnerships with the Coordinating Center (CC), the Lab Network, the
ECHO DC, the Metabolomics Workbench, and others. These relationships, along with our existing CHEAR
infrastructure, singular expertise, and established processes, will carry over to the creation of the HHEAR DC
and will help accelerate its rollout. These services will give the HHEAR community the ability to discover new
correlations and relationships between multi-scale and multimodal data sets, thus progressing toward the
promise of big data to help solve the major challenges of human environmental health research across the
lifecourse. Combining data from a set of individual studies would likely require substantial work if it were
attempted without resources similar to those of the HHEAR DMRC; the design of the data repository will
facilitate manageable and efficient combining of existing data sets; the availability of common vocabularies
developed by the DSR will contribute to maximizing the usable data from each study; and the SSAR will
ultimately receive a dataset to which they can apply their exposome-related analytic methods to address
hypotheses on the environmental health of the pooled study population. Our state-of-the-art DRMC has been
fulfilling these roles within the CHEAR program, and will build on and extend our capabilities as the HHEAR
DC. In sum, leveraging our existing infrastructure and expertise will overcome the need for a long
implementation process fraught with challenges — we have already encountered and overcome many such
challenges in implementing the CHEAR DC, and will be able to flexibly respond to the needs of HHEAR
Network.

## Key facts

- **NIH application ID:** 10006827
- **Project number:** 5U2CES026555-03
- **Recipient organization:** ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- **Principal Investigator:** Patricia Kovatch
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,086,551
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006827

## Citation

> US National Institutes of Health, RePORTER application 10006827, Data Repository and Management Core (5U2CES026555-03). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10006827. Licensed CC0.

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