# Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome

> **NIH NIH R01** · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · 2020 · $626,702

## Abstract

ABSTRACT
Given the high prevalence and substantial impact of mental illness on individuals with intellectual disabilities
(ID) studies that examine mental health in persons with ID are critical to direct treatment aimed at reduction
and, more importantly, prevention of mental illness to improve functioning and quality of life. Fragile X
syndrome (FXS) is the leading identified cause of ID with up to 80% of adolescents and adults with FXS
meeting criteria for an anxiety disorder. FXS is an ideal model to investigate the combined and interactive
effects among biological, behavioral and environmental factors on the emerging trajectory of anxiety in persons
with ID. This application “Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome” proposes the
first longitudinal prospective developmental study of the early features of anxiety in very young boys with FXS
contrasted to boys diagnosed with ASD (non-FXS) and typical controls (TD). We are interested in the age at
which initial features of anxiety can be detected and the stability and prognostic value of these early symptoms to
diagnostic categorization across two populations associated with ID and at high risk for anxiety. Likewise, we are
interested in documenting factors that predict the emergence, stability and severity of anxiety in these two
populations.

## Key facts

- **NIH application ID:** 10006859
- **Project number:** 5R01MH107573-05
- **Recipient organization:** UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
- **Principal Investigator:** Jane E Roberts
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $626,702
- **Award type:** 5
- **Project period:** 2016-09-01 → 2023-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10006859

## Citation

> US National Institutes of Health, RePORTER application 10006859, Emergence, Stability and Predictors of Anxiety in Fragile X Syndrome (5R01MH107573-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10006859. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*