# Human Subjects and Clinical Phenotyping Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $233,038

## Abstract

PROJECT SUMMARY/ABSTRACT – Human Subjects and Clinical Phenotyping Core 
The Human Subjects and Clinical Phenotyping (HSCP) Core will provide researchers with access to a full 
range of services to facilitate successful identification and recruitment of human subjects for basic, clinical and 
translational research studies in rheumatic diseases. The Core will streamline clinical research infrastructure, 
including study design, research ethics consultation, patient recruitment, clinical informatics and disease 
expertise, to advance precision medicine in rheumatic disease. We propose the following Aims for the HSCP 
Core: 1) To provide consultation on human subjects study design, data collection, outcome measures, and 
research ethics for basic, clinical and translational research studies of rheumatic disease; 2) To facilitate 
identification of human clinical phenotypes for research studies, leveraging collaborations between nationally 
recognized disease experts and clinical informaticists; 3) To offer state-of-the art data retrieval and 
management resources, including construction of electronic health record-enabled registries; and 4) To 
coordinate and provide resources for human subject recruitment and biospecimen collection. Advancing 
precision medicine in rheumatic diseases will require a patient-oriented approach that optimizes coordination of 
these highly specialized resources across projects. Key strengths of the Core include internationally renowned 
clinical experts in rheumatology, national leaders in clinical research and clinical informatics, expertise in 
human subjects research ethics, and unique expertise in including patients from high-risk and diverse 
populations, including racial/ethnic minorities and those with low socioeconomic status. HSCP Core services 
address some of the current challenges facing the research community studying rheumatic diseases. These 
include the need for highly accurate clinical phenotyping given the extreme heterogeneity of disease 
manifestations in rheumatic diseases such as systemic lupus erythematosus, vasculitis, scleroderma and 
others; the need to more efficiently identify and recruit patients for clinical studies, particularly those with 
uncommon or rare diseases or clinical phenotypes; and the current lack of coordination of research 
infrastructure across ongoing studies, leading to inefficiencies in patient recruitment, data collection, and data 
management. Innovations of the HSCP Core include leveraging robust existing clinical informatics 
infrastructure to bridge the divide between the vast amount of accumulating clinical data and individual 
investigators who are interested in specific clinical phenotypes of rheumatic diseases; querying “big data” from 
electronic health records to construct registries using specialized methods; and “match-making” between 
investigators and resources. The overall goal of these activities is to provide critical and cutting edge 
resources that c...

## Key facts

- **NIH application ID:** 10007631
- **Project number:** 5P30AR070155-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Patricia P Katz
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $233,038
- **Award type:** 5
- **Project period:** 2016-09-21 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10007631

## Citation

> US National Institutes of Health, RePORTER application 10007631, Human Subjects and Clinical Phenotyping Core (5P30AR070155-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10007631. Licensed CC0.

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