# Genomics and Molecular Resources Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $118,568

## Abstract

PROJECT SUMMARY/ABSTRACT – Genomics and Molecular Resources Core
The overall goal of our Center is to advance precision medicine in the rheumatic diseases. The Genomics and
Molecular Resources (GMR) Core will play a critical role in our Center by facilitating access to biospecimens
from well-characterized rheumatic disease patients, and providing consultative and coordination services to
ensure appropriate use of genomics, proteomics, and other molecular technologies that have the potential to
advance precision medicine in rheumatology. The GMR Core will streamline laboratory research
infrastructure, including acquisition, processing, storage and management of biospecimens by consolidating
existing rheumatology biospecimens at UCSF and establishing a state-of-the-art Laboratory Information
Management System (LIMS) that will enable us to expand sample collection and create an accessible
biorepository. These activities will occur within the laboratory of Dr. Pui-Yan Kwok, Co-Director of the GMR
Core, whose experience as Faculty Director of the UCSF Genomics Core over the past decade makes him
highly qualified to direct these activities. Core leadership will also provide consultation related to the
appropriate application of genomics and molecular assays (including proteomic and immunologic phenotyping)
and will serve as a liaison between investigators and laboratory personnel to ensure that consistently high
quality genomic and molecular phenotyping data are obtained. A panel of genomics and molecular
phenotyping experts will serve as consultants for P30 investigators and projects, covering a wide range of
expertise including genomics, epigenetics, proteomics, immune phenotyping, lymphocyte signaling,
microbiome analysis, and production of pluripotent stem cells. The GMR Core will work closely with the
Human Subjects and Clinical Phenotyping (HSCP) Core to coordinate selection of the appropriate rheumatic
disease patients and clinical data for Center studies, and with the Integrative Bioinformatics (IB) Core to
integrate genomic and molecular data with clinical data for statistical analysis. Key strengths of the GMR Core
include the substantial existing rheumatic disease biospecimens that will be consolidated and centrally
managed using a state-of-the-art LIMS; internationally renowned experts in genomics and molecular
phenotyping for rheumatic, autoimmune and other disorders; facilities for generating state-of-the-art genomics
and other molecular phenotyping data from human biospecimens; and visibility locally, nationally, and
internationally to facilitate outreach activities of the Center to advance precision medicine in rheumatic disease
research.

## Key facts

- **NIH application ID:** 10007633
- **Project number:** 5P30AR070155-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Pui-Yan KWOK
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $118,568
- **Award type:** 5
- **Project period:** 2016-09-21 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10007633

## Citation

> US National Institutes of Health, RePORTER application 10007633, Genomics and Molecular Resources Core (5P30AR070155-05). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10007633. Licensed CC0.

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