# Integrative Bioinformatics Core

> **NIH NIH P30** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $165,601

## Abstract

PROJECT SUMMARY/ABSTRACT – Integrative Bioinformatics Core
Precision medicine is an emerging integrative approach for disease prevention, early detection and treatment
that takes into account individual variability in genetics, medical history, environmental exposures, and lifestyle.
The development and availability of genomic and other molecular profiling technologies in combination with the
deployment of electronic health records (EHR) provide an unprecedented opportunity to apply precision
medicine strategies in rheumatic disease research. The overall goal of the Integrative Bioinformatics (IB) Core
is to provide researchers with access to state-of-the-art computational approaches for the study of rheumatic
disorders. Directed by leading experts in computational biology and bioinformatics, the IB Core will provide
investigators with assistance in study design, bioinformatics data analysis, data integration and data
dissemination. To advance rheumatic disease research in the context of precision medicine, the IB Core will
provide project consultation, education, and outreach for the Center community, as well as the analysis and
integration of high quality genomics, molecular and clinical data. In collaboration with the Genomics and
Molecular Resources (GMR) and Human Subjects and Clinical Phenotyping (HSCP) Cores, the IB Core will
assist researchers with bioinformatics analysis to advance precision medicine in rheumatology. With those
goals in mind we propose the following aims. In Aim 1, we will provide analytical consulting services in study
design, data analysis and data integration with public datasets in order to advance precision medicine in
rheumatic disease research. In Aim 2, the IB Core will develop novel tools, software and analytical pipelines
for the integration, annotation, analysis, retrieval, and presentation of data from clinical and molecular studies
of rheumatic diseases. As a result of this Aim, we will furthermore establish and maintain a technologically up-
to-date toolset that can be readily used for systems-level analyses of the data. Aim 3 is to integrate molecular
and clinical data and leverage collaborations between the GMR and HSCP Cores and facilitate integrative
computational analysis for a wide range of clinical, translational and basic research studies to enable precision
medicine in rheumatology. Finally, in Aim 4, we will provide centralized data management and storage
including assistance in dissemination of data for P30 associated projects using the Immunology Database and
Analysis Portal (ImmPort). The IB Core will bring together researchers from different backgrounds and enable
investigators whose work can benefit from access to state-of-the-art computational technologies and
approaches, with an overall goal of advancing precision medicine in rheumatology.

## Key facts

- **NIH application ID:** 10007634
- **Project number:** 5P30AR070155-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** MARINA SIROTA
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $165,601
- **Award type:** 5
- **Project period:** 2016-09-21 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10007634

## Citation

> US National Institutes of Health, RePORTER application 10007634, Integrative Bioinformatics Core (5P30AR070155-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10007634. Licensed CC0.

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