# IMPaCT 2.0

> **NIH NIH U54** · MOREHOUSE SCHOOL OF MEDICINE · 2020 · $120,050

## Abstract

7. PROJECT SUMMARY 
African Americans (AAs) are more likely to develop and die from cancer than any racial and ethnic group in the 
United States (U.S.). Over the past two decades, there has been an increased focus on participation of AAs in 
cancer clinical trials (CCTs) to address this disproportionate burden of cancer; however AAs continue to be 
underrepresented in CCTs. The dearth of AAs participating in CCTs diminishes the generalizability of results of 
trials. If AAs remain underrepresented in CCTs, the implications include slower progress in elucidating the 
underlying causes of long-standing health disparities in cancer outcomes. There is an extensive body of 
science detailing trial participation barriers among AAs, including limited access to specialty care centers 
where trials are conducted, competing work obligations, and fear and mistrust of clinical research. Despite 
these barriers, AAs are, inherently, no less willing to participate in CCTs or other types of research studies than 
other racial or ethnic groups. The absence of differences in willingness to participate suggests that persistent 
disparities in accrual may, in fact, be due to AAs being offered fewer opportunities than whites to participate in 
CCTs. Although many interventions have focused on approaches to increase the willingness of AAs to 
participate, perhaps efforts should be focused on increasing the opportunities among AAs to participate in 
CCTs. We propose to adapt the IMPaCT patient navigation model and pilot a clinical trials navigator program, 
IMPaCT 2.0, at Morehouse Healthcare (MH) and Grady Hospital (Grady), one of the largest safety-net 
hospitals in the nation. We propose to enhance the patient navigation model with a mobile tablet-based clinical 
trial tracking system (CTTS) (using i2b2 software) to facilitate increased engagement among AA patients 
regarding CCT participation opportunities and to address deficits in the research infrastructure at these two 
institutions. Utilizing a qualitative approach, we will identify those barriers and facilitators to AA recruitment at 
MH/Grady (Specific Aim 1) and incorporate those findings into an adapted clinical trials navigation (CTN) 
model with an integrated mobile tablet CTTS (Specific Aim 2)., We will implement IMPaCT 2.0 at MH/Grady 
breast and prostate cancer clinics and evaluate, in a one-group, pre-/post-test design, the feasibility and 
acceptability (Specific Aim 3).

## Key facts

- **NIH application ID:** 10007641
- **Project number:** 5U54CA118638-15
- **Recipient organization:** MOREHOUSE SCHOOL OF MEDICINE
- **Principal Investigator:** Brian M. Rivers
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $120,050
- **Award type:** 5
- **Project period:** 2005-09-30 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10007641

## Citation

> US National Institutes of Health, RePORTER application 10007641, IMPaCT 2.0 (5U54CA118638-15). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10007641. Licensed CC0.

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