# Autophagy Scientific Core

> **NIH NIH P20** · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · 2020 · $264,151

## Abstract

SUMMARY
In support of the Autophagy, Inflammation and Metabolism (AIM) Center of Biomedical Research Excellence
(CoBRE), the Autophagy Science Core (ASC) will centralize expertise, training, and instrumentation for high
quality autophagy assays. Although the University of New Mexico Health Science Center (UNM HSC) enjoys a
breadth of investigator expertise in various disease states, a centralized facility is needed to support autophagy
investigations. The ASC facility will enable AIM mentored PIs (mPIs) and a growing cadre of investigators at
UNM HSC, statewide, and regionally to implement autophagy assays into their research. In support of the AIM
CoBRE mission, these centralized ASC resources will accelerate the mPI trajectory toward independent NIH-
R01 level funding, thus, side-stepping the steep learning curve mPIs typically face. ASC will share a newly
remodeled space—the scientific cores lab (SCICORE lab)—and will interface with the AIM Inflammation and
Metabolism Core. For different applications the two scientific cores will share an AMNIS ImageStream X Mark
II flow cytometer and will jointly participate in its upgrades, applications, development and oversight through
the expertise of a single technical support staff. Also ASC will maintain an autophagy transgenic animal colony
with expert genotyping and phenotype quality control. ASC will not duplicate the existing shared equipment
and will fully interface with existing facilities at UNM HSC and with existing cores at other Institutional
Development Award (IDeA) centers in New Mexico. Furthermore, ASC will foster multidisciplinary interactions
between established and junior investigators at UNM HSC and regionally by supporting research in a wide
range of autophagy-implicated fundamental processes and disease states. The following specific aims will be
accomplished:
 Specific Aim 1. Create a unique single resource to provide both expertise and experimental capabilities in
autophagy techniques and research
 Specific Aim 2. Enable and enhance the autophagy research of mentored PIs and develop the new
cohorts of CoBRE investigators to study autophagy in the contexts of inflammation and metabolism.
 Specific Aim 3. Lead, coordinate, and develop autophagy research across UNM HSC and the state.
 Achieving these aims will facilitate R01 attainment of the current roster of mPIs; develop a new cadre of
investigators using autophagy measures; establish a long-term sustainable core to enable AIM research; and
support research at UNM HSC, statewide, and in regional IDeA states. ASC, and by extension AIM, will
become a national resource through technical workshops and other modes of dissemination.

## Key facts

- **NIH application ID:** 10007918
- **Project number:** 5P20GM121176-04
- **Recipient organization:** UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
- **Principal Investigator:** LARRY A. SKLAR
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $264,151
- **Award type:** 5
- **Project period:** 2017-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10007918

## Citation

> US National Institutes of Health, RePORTER application 10007918, Autophagy Scientific Core (5P20GM121176-04). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10007918. Licensed CC0.

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