# Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkers

> **NIH NIH K01** · UNIVERSITY OF FLORIDA · 2020 · $159,649

## Abstract

Project Summary/Abstract
 This project will investigate important hypotheses regarding the relationship between regional cerebral γ-
aminobutyric acid (GABA) concentrations and cognitive flexibility in HIV+ heavy drinkers. To ensure an
independent career post award, two critical areas of training will be addressed: 1) Behavioral and biological
consequences of alcohol use in the context of HIV and 2) the development of expertise in the measurement of
γ-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter, using Magnetic Resonance
Spectroscopy (MRS). The PI is a cognitive neuroscientist with a strong research background in aging,
cognition, experimental design, autonomic measurement, and magnetic resonance imagining (fMRI & MRI).
 The K01 will provide protected time and training for the PI to focus his research agenda firmly in alcohol
and HIV. Specifically, the K01 will enable the PI to conduct cutting edge non-invasive research investigating
the biological foundations of the well documented behavioral, cognitive, and health alterations resulting from
HIV and heavy drinking. This training will provide the skills and knowledge required to translate the PI's basic
science skills into clinical translational applications exploring the interaction between HIV+ and heavy drinking.
 The proposed research will investigate: (A) the relationship between GABA concentrations and heavy
alcohol use in individuals with HIV, and (B) the relationship between GABA and cognitive flexibility in
individuals with HIV. To investigate these research questions, cognitive capabilities and cortical GABA
concentrations will be examined. 35 million people have contracted HIV worldwide, more than 1.2 million people
have HIV in the US, with more than 50,000 new diagnoses each year. HIV+ individuals exhibit almost twice the rate of
heavy alcohol consumption in contrast to the general population. Heavy alcohol consumption in HIV+ adults, impacts
on health outcomes by increasing the occurrences of high-risk behaviors and is associated with increased severity of
brain dysfunction. Thus, heavy alcohol consumption in HIV+ is a major public health concern. To assess GABA,
GABA concentrations will be measured using MEGA-PRESS MRS in 2 frontal regions that have been
implicated in cognitive flexibility and a posterior region of the brain. Measures of Cognitive flexibility will be
measured via neuropsychological testing. We hypothesize that: 1) Lower GABA concentrations will be related
to heavy drinking and HIV, with hazardous drinking HIV+ adults having the lowest concentrations of GABA 2)
Reduced GABA concentrations in frontal regions will be associated with reduced cognitive flexibility.

## Key facts

- **NIH application ID:** 10009253
- **Project number:** 5K01AA025306-04
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Eric Porges
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $159,649
- **Award type:** 5
- **Project period:** 2017-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10009253

## Citation

> US National Institutes of Health, RePORTER application 10009253, Cognitive and functional deficits associated with reduced cortical GABA in HIV-infected heavy drinkers (5K01AA025306-04). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10009253. Licensed CC0.

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