# Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR

> **NIH NIH P41** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $378,417

## Abstract

Project Summary
PET and MRI offer complementary views of physiology and the ability to measure data from both modalities
concurrently provides a unique opportunity to study biological mechanisms in ways that were heretofore
impossible to realize in intact animals, including human subjects. However, this advance in hardware and data
acquisition poses new challenges for data analysis and interpretation due to the fact that the modalities are
based upon different physical principles and generally reflect different in vivo phenomena. Conceptually, we
address the problem and seize the opportunity via integrated PET/MR analysis frameworks wherein shared
physiological mechanisms mathematically link quantitative PET and MR models, improving the accuracy and
precision of physiological measurements and, in several instances, permitting outcomes not achievable using
either modality alone. This general approach is proposed for development in several specific and illustrative
cases – neurotransmission, mitochondrial membrane potential, and oxidative stress – that together span
diverse organ systems, physiological processes, and potential disease applications.

## Key facts

- **NIH application ID:** 10009341
- **Project number:** 5P41EB022544-04
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Marc David Normandin
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $378,417
- **Award type:** 5
- **Project period:** 2017-09-30 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10009341

## Citation

> US National Institutes of Health, RePORTER application 10009341, Pharmacokinetic Physiologic Modeling in Simultaneous PET/MR (5P41EB022544-04). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10009341. Licensed CC0.

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