ABSTRACT More than two in three (70.2%) U.S. adults are overweight or obese (Body Mass Index (BMI) of ≥ 25).1 Hispanics are 23% more likely to be obese than their White counterparts4, and obesity rates are higher in Hispanic women than Hispanic men (45% vs. 39.7, respectively).5 Obesity is driven by a variety of social, physical, and economic factors, but is mainly due to poor diet and physical inactivity.2,7 Hispanics are more likely than non-Hispanic Whites to engage in these risk behaviors10-13 Given this, most successful interventions that reduce adiposity indices (e.g. BMI, weight, waist circumference) incorporate both diet and exercise21-23 Nonetheless, most obesity research is based on a general non-Hispanic population. Culturally adapted health interventions substantially improve the outcomes in minority groups compared to generic programs26-30 including culturally tailored obesity programs for Hispanics.31 Successful obesity interventions for Hispanics have relied on promotores de salud (also known as community health workers) as key implementers.31 Promotores are effective in delivering obesity interventions 31,37,40,42, however, adequate in-person training of the promotora is necessary for effective implementation of these interventions. An in-person train-the-trainer model is a laudable means of investing in promotores and communities, however, there remains barriers to accessibility of training due to promotores availability, family commitments and associated costs.43,58-60 Our goal is to develop an effective, accessible, and scalable obesity prevention training program for promotores. We aim to develop Comadres Saludables, an interactive, web-based (and tablet compatible) promotora training for obesity prevention in Hispanic women. Comadres Saludables will : 1) combine both theory and evidence-based practices to provide promotores with the knowledge and skills required to effectively implement an obesity intervention for Hispanic women; and 2) provide promotores with interactive mHealth tools to enhance implementation with Hispanic populations. The training program will aim to increase knowledge and skills by incorporating interactive activities such as interactive quizzes, exercises, video role- playing scenarios, and tools. A booster module aimed at providing continuous support and education for promotores will also be included in the program. Lastly, interactive mHealth tools will be accessible to promotores to aid in implementation and fidelity monitoring. In Phase I, with input from focus groups and our expert consultants, ISA staff will develop and pilot test Comadres Saludables, a prototype promotora training program for obesity prevention. Community Action Corporation of South Texas (CACOST) will provide ISA with an Advisory Committee that will participate in a focus group and aid in the iterative process of developing the prototype. In addition, CACOST will help us recruit certified promotores from the area. Certified pr...