# Genotyping Core

> **NIH NIH P30** · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · 2020 · $114,915

## Abstract

ABSTRACT
Genotyping Core
The Genotyping Core provides investigators comprehensive services in genotyping a broad range of
transgenic and mutant mouse strains in a fast and accurate manner that is critical to the analysis and
interpretation of the data. The generation of conditional deletion of genes involves a complex breeding pattern
and creates multiple lines. Accurate genotyping is vital to validate the successful targeted gene or genes to
identify the final genotypes. Efficient and timely analysis of mouse genotypes greatly facilitates the
management of PI mouse colonies and allows for the culling of unwanted genotypes in a timely fashion. This
process expedites the PIs to manage their mouse lines and reduce the costs of housing. The Genotyping Core
allows us to take much of the burden of genotyping multiple lines from lab personnel and to streamline and
better maintain our mouse colonies. A second major advantage is the expertise of screening for genetic
polymorphisms expressed in several inbred mouse lines that can impact the results of our work, e.g., rd1 and
rd8 mutations and rpe65 polymorphisms. The Genotyping Core is especially helpful to the junior investigators
who may not have this expertise in their lab and cannot afford to hire someone for this service. Furthermore,
multiple genotyping requires different protocols to analyze the genotypes: different protocols are a time-
consuming exercise. The core will standardize these protocols for the PI and provide support to scientists in
their genotyping projects in every aspect of research, including planning, extracting DNA, genotyping,
interpreting data, and doing statistical analysis.

## Key facts

- **NIH application ID:** 10011812
- **Project number:** 5P30EY021725-10
- **Recipient organization:** UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- **Principal Investigator:** DANIEL J CARR
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $114,915
- **Award type:** 5
- **Project period:** 2011-09-01 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10011812

## Citation

> US National Institutes of Health, RePORTER application 10011812, Genotyping Core (5P30EY021725-10). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10011812. Licensed CC0.

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