# Whole brain circuit mapping of transplanted interneurons following traumatic brain injury

> **NIH NIH F31** · UNIVERSITY OF CALIFORNIA-IRVINE · 2020 · $41,295

## Abstract

PROJECT SUMMARY/ABSTRACT
The loss of inhibitory interneurons after traumatic brain injury has been associated with the development of
epilepsy and other deficits in cognition. Our lab has previously demonstrated that embryonic interneuron
progenitors transplanted into the brain migrate, differentiate, and functionally integrate into host-brain networks,
and can suppress spontaneous seizures and ameliorate learning and memory deficits in a mouse model of
epilepsy. Transplanted interneurons exhibit mature morphologies and electrophysiological properties
characteristic of endogenous interneurons. However, the cell types and brain regions that innervate
transplanted interneurons are currently unknown. The goal of this proposal is to use a rabies virus tracing
strategy, whole-brain clearing, and intact-brain imaging to map cell-type specific monosynaptic inputs onto
interneurons grafted into the healthy and injured hippocampus.

## Key facts

- **NIH application ID:** 10012950
- **Project number:** 5F31NS106806-03
- **Recipient organization:** UNIVERSITY OF CALIFORNIA-IRVINE
- **Principal Investigator:** Jan Christopher Frankowski
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $41,295
- **Award type:** 5
- **Project period:** 2018-09-30 → 2021-09-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10012950

## Citation

> US National Institutes of Health, RePORTER application 10012950, Whole brain circuit mapping of transplanted interneurons following traumatic brain injury (5F31NS106806-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10012950. Licensed CC0.

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