# Admin Core: Identifying genes and Pathways that impact Tau Toxicity in FTD

> **NIH NIH U54** · MAYO CLINIC  JACKSONVILLE · 2020 · $35,213

## Abstract

PROJECT SUMMARY/ABSTRACT
The overarching theme of this new Center without Walls (CWOW) proposal entitled “Identifying genes and
pathways that impact tau toxicity in FTD” is to discover novel genetic modifiers of tauopathy to provide
unique insight into disease mechanisms, as well as to develop and validate an innovative approach to measure
tau burden in patients using plasma samples. Core A will facilitate these goals by providing scientific and fiscal
oversight and promoting the Center's scientific governance strategy to ensure the synergy and integration of
each core and project. Core A will be responsible for managing fiscal responsibilities for the Center, ensuring
ethical and responsible conduct of research, providing scientific direction and accountability, and reporting
progress to the NIH and to the public. In order to ensure the success of this research proposal, Core A will
also leverage Mayo Clinic resources to foster a multidisciplinary and cross-institutional program that advances
research, generates valuable biological resources, and promotes education and resource sharing with the field.
Core A will avail itself of Mayo Clinic institutional resources on behalf of the Center for administrative
assistance with grants administration and aspects of human subject research, as well as coordinate and
leverage the institutional resources at the other sites, including the various relationships and memberships the
project and core leaders have with many external organizations and consortia. To accomplish these goals,
Core A will pursue the following specific aims. Specific Aim 1: Provide administrative structure and fiscal
oversight for the CWOW. Specific Aim 2: Assume responsibility for the quality control of the Center's activities
by ensuring responsible conduct of research. Specific Aim 3: Promote the scientific direction and integration
of the Center components by organizing regular Executive Steering Committee meetings and overseeing
external collaborations that support the Center cores and projects. Specific Aim 4: Establish an External
Advisory Committee and report progress to the NIH. Specific Aim 5: Establish and maintain the Center
website. Specific Aim 6: Promote education on FTLD and related tauopathies, and encourage CWOW
investigators to participate in patient and caregiver support groups.

## Key facts

- **NIH application ID:** 10012955
- **Project number:** 5U54NS100693-05
- **Recipient organization:** MAYO CLINIC  JACKSONVILLE
- **Principal Investigator:** LEONARD PETRUCELLI
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $35,213
- **Award type:** 5
- **Project period:** 2016-09-30 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10012955

## Citation

> US National Institutes of Health, RePORTER application 10012955, Admin Core: Identifying genes and Pathways that impact Tau Toxicity in FTD (5U54NS100693-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10012955. Licensed CC0.

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