# Neurovascular and Neuroplastic Contributions to Visual Recovery After Stroke > **NIH NIH F30** · UNIVERSITY OF ROCHESTER · 2020 · $50,520 ## Abstract Abstract Stroke is a leading cause of serious long-term adult-onset disability in the United States, with 25% of stroke patients experiencing some type of visual field deficit. Stroke in the territory of the posterior cerebral artery (PCA) causes blindness in all or parts of the visual hemi-field contralateral to the lesion. This blind field begins to contract within the first 10 days following stroke with some patients continuing to improve out to 6 months. While about 50% of patients experience some degree of visual improvement, only 12.5% of patients experience complete recovery. The underlying mediators of recovery remain poorly understood due to the brain's multifaceted response to ischemic injury. We test the hypothesis that post-stroke recovery is associated with: 1) neurovascular repair and 2) experience-dependent induction of neuroplasticity. To test this hypothesis, the proposed project details a longitudinal study of changes in visual perception and neural activity in stroke patients at 1 week, 1 month, and 3 months after stroke in the territory of the PCA. Visual recovery will be quantified with a clinical neuro-ophthalmological test of perceptual vision and correlated with different measures of neural activity using functional magnetic resonance imaging (fMRI). Aim 1 tests the hypothesis that spontaneous visual recovery at 1 month, but not additional spontaneous recovery at 3 months, is specifically due to normalization of the perilesional tissue's neurovascular response to visual stimuli. This normalization could reflect recovery of previously dysfunctional ischemia-resilient neurons and/or vascular repair. The neurovascular response will be quantified at each time point with fMRI by calculating the time to peak activation following presentation of a full-field visual stimulus. Aim 2 tests the hypothesis that tuning curve widening in perilesional cortex differentially underlies spontaneous perceptual visual recovery at 1 month, while shifts in the preferred retinotopic focus of perilesional voxels differentially explains additional spontaneous visual recovery at 3 months. This hypothesis is consistent with a model of post-stroke neuroplasticity in the motor cortex in which there is an initial non-specific expansion of activation that later consolidates and regains specificity but for a different location. These changes in a perilesional voxel's activation profile will be quantified from fMRI runs in which the patient views a pseudo-random presentation of flickering checkerboard wedges in 12 non-overlapping locations. The degree to which each voxel responds to each wedge location will constitute that voxel's spatial location tuning curve. Understanding how the brain's response after stroke influences visual perception will inform neuroplasticity research, clinical targets for rehabilitation treatments, outcome measures for clinical trials, and best practices for conducting fMRI research in a patient population with altered neurovascu... ## Key facts - **NIH application ID:** 10013197 - **Project number:** 5F30EY027988-03 - **Recipient organization:** UNIVERSITY OF ROCHESTER - **Principal Investigator:** Colleen L Schneider - **Activity code:** F30 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2020 - **Award amount:** $50,520 - **Award type:** 5 - **Project period:** 2018-09-24 → 2022-09-23 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10013197 ## Citation > US National Institutes of Health, RePORTER application 10013197, Neurovascular and Neuroplastic Contributions to Visual Recovery After Stroke (5F30EY027988-03). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10013197. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*