# Component: Husbandry and Management Core

> **NIH NIH U42** · OREGON HEALTH & SCIENCE UNIVERSITY · 2020 · $1,412,907

## Abstract

PROJECT SUMMARY, Core A: Husbandry and Management Core
Expanded SPF (eSPF) rhesus macaques (Macaca mulatta), which are defined as being negative to rhesus
rhadinovirus, simian immunodeficiency virus, simian foamy virus, simian T-lymphotropic virus, simian
retrovirus, macacine herpesvirus-1 (BV), measles, and rhesus cytomegalovirus, are necessary to study an
increasing range of viruses important to human health, as well as the development and testing of novel viral
vectors. eSPF macaques have become the premier animal model for HIV/AIDS research, including studies on
HIV pathogenesis, AIDS-related opportunistic infections, and the development of HIV treatments and vaccines.
Currently, the national need for genetically characterized eSPF rhesus macaques for HIV/AIDS research far
exceeds the current availability. Therefore it is imperative that the available eSPF rhesus macaque
populations grow in size. The successful maintenance of expanded SPF colonies is challenging, however,
and requires strict management practices in order to remain specific pathogen free. With over 18 years’
experience in establishing and maintaining a colony of eSPF animals, the ONPRC is the leader at managing
eSPF rhesus macaques. The overall aims of the Husbandry and Management Core are to breed and grow the
ONPRC eSPF colony in order to meet existing and future animal resource demands, continue to provide and
improve upon the existing exemplary eSPF husbandry and veterinary care, and to improve the eSPF resource
by making the entire colony lymphocryptovirus negative. To do this we will provide innovative team based
management practices including expansion of the colony into outdoor sheltered housing, introduction of a time-
mated breeding program and artificial insemination, a foster mother program for abandoned infants,
implementation of new enrichment and social monitoring strategies, and re-derivation of LCV negative infants
from within the eSPF colony.

## Key facts

- **NIH application ID:** 10014301
- **Project number:** 2U42OD023038-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Kamm Prongay
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,412,907
- **Award type:** 2
- **Project period:** 2016-08-01 → 2024-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10014301

## Citation

> US National Institutes of Health, RePORTER application 10014301, Component: Husbandry and Management Core (2U42OD023038-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10014301. Licensed CC0.

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