# Metabolism Core

> **NIH NIH P20** · ARKANSAS CHILDREN'S HOSPITAL RES INST · 2020 · $172,958

## Abstract

PROJECT SUMMARY 
Through this COBRE application, we seek to establish the Center for Childhood Obesity Prevention. The goal 
of the Metabolism Core C is to provide support for metabolic studies, including exercise studies and biological 
sample analyses, for projects in the Center. It is recognized that suboptimal nutrition and exercise are 
important factors in the development of obesity, and that improvement of these factors are vital for the reversal 
of obesity and its corresponding disturbances in metabolism. The structure of this improvement is however 
debated, e.g., can exercise alone, without changes in bodyweight, improve obesity related metabolic 
disturbances. The Metabolism Core (MC) includes a physical activity facility for controlled studies of exercise 
and substrate metabolism, a special procedure/testing facility, and an analytical lab for analyses of biological 
samples. The MC will assist and mentor the junior investigators in the performance of metabolic studies, 
including use of stable isotope tracer techniques to measure metabolic rates, and will assist in design of future 
fundable studies of metabolism in obesity. Among the primary junior investigator projects, focus will be on the 
response of lean and obese children and also obese pregnant women, to nutritional interventions (probiotics, 
amino acids or protein). The effects of interventions on insulin sensitivity, fat oxidation, whole body protein 
turnover (synthesis and breakdown), and plasma and liver lipid content/hepatic steatosis, will be determined. 
The MC will also serve to educate and support the COBRE junior investigators in measurement of physical 
activity and biological responses in community/field studies. Thus, the core adds to the uniqueness of the grant 
in that lab studies and community studies of obesity are bridged in a translational manner. The Metabolism 
Core is NEW to the revised application.

## Key facts

- **NIH application ID:** 10014635
- **Project number:** 5P20GM109096-05
- **Recipient organization:** ARKANSAS CHILDREN'S HOSPITAL RES INST
- **Principal Investigator:** Elisabet Borsheim
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $172,958
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10014635

## Citation

> US National Institutes of Health, RePORTER application 10014635, Metabolism Core (5P20GM109096-05). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10014635. Licensed CC0.

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