# The Pacific Northwest Prostate Cancer SPORE

> **NIH NIH P50** · FRED HUTCHINSON CANCER RESEARCH CENTER · 2020 · $2,074,098

## Abstract

PROJECT SUMMARY/ABSTRACT
The Pacific Northwest (PNW) Prostate Cancer SPORE continuation grant represents a coordinated effort of four
institutions with established programs and strengths in translational prostate cancer research including basic,
clinical, and population sciences as well as career development: 1) the Fred Hutchinson Cancer Research
Center (FHCRC); 2) the University of Washington (UW) and its affiliated institutions; 3) the University of British
Columbia and the Prostate Centre of Vancouver General Hospital (UBC); and 4) Oregon Health and Science
University (OHSU). These Seattle-, British Columbia- and Portland-based institutions have large multidisciplinary
teams of investigators and laboratories dedicated to prostate cancer research and a history of working closely
together within this larger milieu. The respective teams of clinicians and researchers at these institutions bring
considerable scientific depth, breadth, creativity, and vision required for confronting the most challenging
problems blocking progress in our ultimate goal of reducing the morbidity and mortality associated with prostate
cancer. This SPORE proposal enlarges the blueprint for a well-built, distinctive and coordinated translational
prostate cancer research effort spanning the entire PNW.
All participating institutions have made substantial commitments toward supporting the SPORE and its
innovative, translational projects: 1) Molecular predictors of prostate cancer progression and mortality; 2)
Targeting Emergent Vulnerabilities in AR-Inactive Prostate Cancer; 3) Oncofetal Glycosaminoglycans as
Molecular Targets in Prostate Cancer; 4) Clinical Development of Therapeutic Strategies Targeting Damage
Repair; and 5) Exploiting mechanisms of response and resistance to next generation androgen pathway
antagonists. We also propose four Cores to support these projects: 1) Leadership and administration; 2)
Biospecimens; 3) Biostatistics and Data Analytics; and 4) Clinical research. In addition, we propose a
Developmental Research Program and a Career Enhancement Program that will significantly embellish and
strengthen the translational goals of our prostate cancer research program and expand opportunities for
engaging young as well as established investigators in our multidisciplinary environment.

## Key facts

- **NIH application ID:** 10016178
- **Project number:** 5P50CA097186-18
- **Recipient organization:** FRED HUTCHINSON CANCER RESEARCH CENTER
- **Principal Investigator:** PETER S NELSON
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,074,098
- **Award type:** 5
- **Project period:** 2002-09-19 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10016178

## Citation

> US National Institutes of Health, RePORTER application 10016178, The Pacific Northwest Prostate Cancer SPORE (5P50CA097186-18). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10016178. Licensed CC0.

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