# Biospecimen Unit

> **NIH NIH U2C** · CHILDREN'S HOSP OF PHILADELPHIA · 2020 · $192,017

## Abstract

Abstract
The objective of the Biospecimen Unit is to provide the necessary infrastructure to
prospectively acquire the highest quality human tumor specimens to support the mission
of the Center for Pediatric Tumor Cell Atlas (CPTCA). Our existing biorepository
infrastructure is modern, stream-lined and highly supported by our institution. Our
leadership role in several similar, large scale multi-institutional projects have changed
the therapeutic approach and standard of care of specific pediatric cancers and provide
further evidence that the structure is already in place to ensure the success of CPTCA.
We will prospectively collect tumor and blood samples from twenty patients for three
major pediatric cancers. We propose the following three specific aims: 1) To acquire,
process and characterize pediatric high-grade glioma biospecimens for the CPTCA
examining the critical genomic transitions from diagnosis to relapse; 2) To acquire,
process and characterize pediatric high-risk neuroblastoma biospecimens for the
CPTCA to define tumor evolution and the clonal dynamic response to chemotherapy and
targeted therapy; 3) To acquire, process and characterize pediatric very high-risk B-cell
acute lymphoblastic leukemia (VHR ALL) biospecimens for the CPTCA for the evolution
of disease through standard therapy and CAR-T cell immunotherapy. At the completion
of this aim, we will provide high quality biospecimens to the Characterization Unit for
comprehensive multi-omic and in situ analyses integrated with a highly annotated
clinical, molecular, pathologic and radiographic database.

## Key facts

- **NIH application ID:** 10016227
- **Project number:** 5U2CCA233285-03
- **Recipient organization:** CHILDREN'S HOSP OF PHILADELPHIA
- **Principal Investigator:** Kristina Ann Cole
- **Activity code:** U2C (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $192,017
- **Award type:** 5
- **Project period:** 2018-09-30 → 2023-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10016227

## Citation

> US National Institutes of Health, RePORTER application 10016227, Biospecimen Unit (5U2CCA233285-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10016227. Licensed CC0.

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