# Precise Minimally InvasiveTreatment of VT Using Non-invasive Mapping.

> **NIH NIH R44** · HEARTLANDER SURGICAL, INC. · 2020 · $885,868

## Abstract

Project Summary
Ventricular Tachycardia (VT) is a major public health problem associated with the majority of the
300,000 cases of sudden cardiac death in the United States each year. The best current therapy for
VT involves drugs to reduce VT episodes plus implantation of a cardiac defibrilator (ICD) that
prolongs life by terminating episodes of VT. Permanent cessation of VT can be achieved by ablation
of the origin site(s) and exit pathway(s) of the arrhythmia. Despite the advantages of this technique,
its adoption has been limited because it is currently appropriate only for the few patients with
hemodynamically stable VT.
This project will create a disruptive, less expensive, more effective, and safer system for minimally
invasive identification and ablation of critical VT sites. It will combine the HeartLander (HL) epicardial
walker with a non-invasive mapping technology and a flexible, needle-based, radio frequency ablation
technique. In prior work we have demonstrated that these technologies can be integrated into a
unified system and have also eliminated major technical risks of the technologies.
In this Fast Track SBIR application, we propose to complete the integration of the technologies and
then verify the efficacy of the system in a Yorkshire swine pig model of VT. Upon successful
completion, we will be ready to advance to the clinic a simpler, safer, more reliable and less
expensive approach to effectively treating the 500,000 annual cases of ventricular tachycardia. We
will also have built the hardware and computation infrastructure to support additional mapping
methodologies that will enable the treatment of complex multi-focal arrhythmias.

## Key facts

- **NIH application ID:** 10016391
- **Project number:** 5R44HL134425-03
- **Recipient organization:** HEARTLANDER SURGICAL, INC.
- **Principal Investigator:** Dwight Meglan
- **Activity code:** R44 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $885,868
- **Award type:** 5
- **Project period:** 2017-08-15 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10016391

## Citation

> US National Institutes of Health, RePORTER application 10016391, Precise Minimally InvasiveTreatment of VT Using Non-invasive Mapping. (5R44HL134425-03). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10016391. Licensed CC0.

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