# CRCNS: The Evolution of the Mammalian Connectome

> **NIH NIH R01** · TRUSTEES OF INDIANA UNIVERSITY · 2020 · $163,678

## Abstract

Nervous systems are complex networks, composed of neurons in various brain regions that are
 interconnected by synaptic connections and inter-regional pathways. While much effort has been
expended to map the connectome of humans and a few model organisms, a more systematic
comparative acquisition and analysis of connectomes across many species is lacking so far. Hence, the
evolutionary processes that have shaped connectome architecture are largely unknown. Here, we
address this gap in knowledge by generating connectivity data from a large set of mammalian species in
order to allow comprehensive and comparative network analysis as well as to relate network features to
 evolutionary anatomic and behavioral adaptations. Lead by experts in magnetic resonance imaging,
 network theory and behavior, this interdisciplinary team will a) create a unique unprecedented data base
of mammalian connectomes (covering 5% of all mammalian species), acquired using cutting-edge
 diffusion imaging and tractography; b) configure and deploy network analysis techniques to mine these
data and discover patterns that trace the evolution of the connectome across species; and c) formulate
and test specific hypotheses that illuminate evolutionary patterns in the relation between brain connectivity
 and behavior. The project will thus create a first-of-its-kind opportunity to study the evolution of the
connectome across the mammalian class.
RELEVANCE (See instructions):
 Complex brain networks enable and support human cognition and behavior. This project will reveal
 principles of network organization across a broad range of species in the mammalian class, including
 those of commonly used model organisms such as non-human primates and rodents. The resulting
 knowledge will illuminate the evolutionary origins of brain networks and thus provide new insights into
 their neurobiological function and dysfunction in humans.

## Key facts

- **NIH application ID:** 10016796
- **Project number:** 5R01MH122957-02
- **Recipient organization:** TRUSTEES OF INDIANA UNIVERSITY
- **Principal Investigator:** OLAF SPORNS
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $163,678
- **Award type:** 5
- **Project period:** 2019-09-11 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10016796

## Citation

> US National Institutes of Health, RePORTER application 10016796, CRCNS: The Evolution of the Mammalian Connectome (5R01MH122957-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10016796. Licensed CC0.

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