# XCSITE 200: Cloud-Enabled Transcranial Current Stimulation Research Solution for Multisite Studies

> **NIH NIH R43** · PULVINAR NEURO LLC · 2020 · $445,723

## Abstract

PROJECT SUMMARY – Pulvinar Neuro LLC, FROHLICH
Transcranial current stimulation is a form of non-invasive brain stimulation that has recently become a key
tool in human neuroscience research and has emerged as a potential treatment strategy for psychiatric
disorders such as depression and schizophrenia. Yet, many questions about TCS remain unanswered and
its clinical potential has not yet been delineated. We believe a key reason for this is that current TCS research
devices do not have the required features for double-blind, placebo controlled studies of targeted stimulation
waveforms. The objective of this proposal is to develop the XCSITE 200, a transformative TCS research
device which will build upon our XCSITE platform. The XCSITE 200 will allow the study of more targeted
stimulation waveforms that carry the promise of increased efficacy in terms of target engagement and
behavior outcomes. In addition, XCSITE 200 devices will be managed via the cloud and thus enable cheaper
and more effective administration of large, multi-site studies, which are essential in order for the technology
to reach FDA clearance. In this Phase I project, we propose to implement custom-waveform and feedback
stimulation in XCSITE 200 as well as perform extensive testing both at the bench and in a human pilot study
(Aim 1) and to finalize and bench-test the cloud-based device and study management infrastructure (Aim 2).
Quantitative milestones for both proposed aims are defined based on component and systems test
benchmarks. The development of XCSITE 200 will enable the next generation of large-scale TCS studies
with individualized and adaptive stimulation strategies targeting specific brain activity patterns to investigate
their causal role in behavior and treat psychiatric disorders caused by altered brain network dynamics (e.g.,
depression and schizophrenia).

## Key facts

- **NIH application ID:** 10016832
- **Project number:** 5R43MH119872-02
- **Recipient organization:** PULVINAR NEURO LLC
- **Principal Investigator:** Flavio Frohlich
- **Activity code:** R43 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $445,723
- **Award type:** 5
- **Project period:** 2019-09-11 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10016832

## Citation

> US National Institutes of Health, RePORTER application 10016832, XCSITE 200: Cloud-Enabled Transcranial Current Stimulation Research Solution for Multisite Studies (5R43MH119872-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10016832. Licensed CC0.

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