# Administrative Core

> **NIH NIH U54** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $598,121

## Abstract

ABSTRACT
The Nephrotic Syndrome Study Network (NEPTUNE) is a collaborative investigational infrastructure of 26 sites
across North America for conducting clinical and translational research on rare kidney diseases presenting as
Nephrotic Syndrome (NS): Focal and Segmental Glomerular Sclerosis (FSGS), Minimal Change Disease (MCD),
and Membranous Nephropathy (MN). The NEPTUNE Administrative Core serves the primary role to manage
and integrate all activities for clinical and translational research across the NEPTUNE sites. It is responsible for
the overall development, implementation, and maintenance of the governance, policies, and infrastructure
required for the clinical studies, pilot and ancillary studies program, career enhancement opportunities, and
outreach activities in the network. Drs. Kretzler, Sedor, Holzman, Gipson, Gadegbeku, and Trachtman will
represent the consortium leadership team. Dr. Kretzler will serve as PI of the consortium. Dr. Sedor will serve as
Administrative Lead, directing day-to-day program planning, coordination, and evaluation of the network. Drs.
Gadegbeku, Mariani, Sedor, Gipson, and Trachtman will co-lead the two longitudinal clinical studies, and Drs.
Kretzler and Gipson will co-lead the Precision Medicine Study. Dr. Holzman will lead the Pilot/Ancillary and
Career Enhancement Programs. Dr. Trachtman will serve as the Clinical Study Liaison, a role designed in
NEPTUNE III to ensure cross-site engagement in Network activities. NephCure Kidney International (NKI) will
provide critical leadership input from the patient perspective. The NEPTUNE Steering Committee (SC) will
continue to be the central governance structure, consisting of voting members of the participating site PIs, patient
advocacy groups, and funding partners at NCATS and NIDDK. The consortium will continue to assign
subcommittees to help plan, implement, and monitor day-to-day activities that impact the success of the
consortium core components. Additional task- or topic-specific working groups are nominated by consortium
members to address specific needs and opportunities in the scope of NEPTUNE's mission. An independent
group of experts in the areas of glomerular disease, precision medicine, biomarker development, and rare
disease research will form an External Advisory Committee and will annually review and advise the Network on
its scientific progress. Clinical protocols will be overseen by an OSMB to monitor research efforts and advise
NEPTUNE investigators. Drs. Gillespie, Zee, and Troost will lead core biostatistical support, data management,
and good data practices (GDP), and ensure cloud-ready datasets for use in the rare disease community. Dr. He
will lead efforts to develop Common Data Elements in NEPTUNE and align with KPMP and other related projects
with the same community-based integrative ontologies. Using the NEPTUNE Ancillary Study Policy, the
consortium will engage public-private partnerships in research collaborations.

## Key facts

- **NIH application ID:** 10017213
- **Project number:** 5U54DK083912-12
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** Matthias Kretzler
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $598,121
- **Award type:** 5
- **Project period:** 2009-09-08 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017213

## Citation

> US National Institutes of Health, RePORTER application 10017213, Administrative Core (5U54DK083912-12). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10017213. Licensed CC0.

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