# WHISH-2-Prevent Heart Failure Study

> **NIH NIH R01** · KENT COUNTY MEMORIAL HOSPITAL · 2020 · $619,461

## Abstract

ABSTRACT
Heart failure (HF) is major and growing public health problem especially in older women. Despite advances in
the treatment of established HF, prognosis remains poor in the elderly, therefore preventive efforts are needed.
Lack of physical activity (PA) is a potent prospective risk factor for HF; while increased levels of PA are
associated with reduced risk of HF in observational studies, the evidence that maintaining high levels of
physical activity or increasing PA in sedentary individuals reduces the risk of heart failure is not presently
available. A novel PA pragmatic trial embedded within the Women's Health Initiative (WHI) entitled WHI
Strong and Healthy trial (WHISH) has been recently funded and will evaluate whether increasing physical
activity, reducing sedentary behavior and increasing muscle strength through resistance training will reduce the
risk of atherosclerotic cardiovascular disease but not the important outcome of HF. WHISH-2-Prevent Heart
Failure will evaluate the effect of this RCT on incident HF and HF burden (all heart failure hospitalizations and
CVD death in those with antecedent HF) as well as perform dose-finding analyses. WHISH-2-Prevent Heart
Failure will be the first, largest, and longest primary prevention exercise trial ever performed in the highest risk
group for HF-elderly women. An imbedded accelerometer study will allow for a dose-finding analysis
regardless of the RCT results using newly developed MET-equivalent indices for elderly women.

## Key facts

- **NIH application ID:** 10017290
- **Project number:** 5R01HL130591-05
- **Recipient organization:** KENT COUNTY MEMORIAL HOSPITAL
- **Principal Investigator:** CHARLES B EATON
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $619,461
- **Award type:** 5
- **Project period:** 2016-08-01 → 2022-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017290

## Citation

> US National Institutes of Health, RePORTER application 10017290, WHISH-2-Prevent Heart Failure Study (5R01HL130591-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10017290. Licensed CC0.

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