# Andrology Core

> **NIH NIH P50** · WEILL MEDICAL COLL OF CORNELL UNIV · 2020 · $150,575

## Abstract

ANDROLOGY CORE B: The diagnostic Andrology resources available to the project leaders is among the
most skilled and comprehensive collection of sperm function tests in the world, because many of these
diagnostic tests are not widely utilized with the advent if in vitro fertilization and intracytoplasmic sperm
injection. However, these assays are extremely advantageous to use for screening to identify the best small
molecule inhibitor of ADCY10 for contraceptive development. The Andrology Core performs routine semen
analysis and strict morphology according to WHO5 specifications, as well as tests of functional changes of
sperm associated with capacitation: the acrosome reaction assay, Cap-Score, Zona-binding assay and
sperm penetration assay as well as hyperactivated motility. Other specialized services not described are
available to Andrology Core investigators.
Specifically, the Andrology Core aims are:
 Aim #1: To recruit and retain fertile control men to serve as semen donors, who will collect semen
 for use in screening tests of candidate male contraceptive agents acting to inhibit
 ADCY10 and other allosteric inhibitors for sperm forms of sAC. Routine semen analysis
 (liquefaction, appearance (color), volume, viscosity, agglutination, aggregation, motility,
 count/density, other cells present (round cells), morphology, vitality ) will be used together with
 history and physical exam to select donors.
 Aim #2: To perform functional tests associated with capacitation. Tests of capacitation to be
 performed include the routine and induced acrosome reaction test, the CaPScore, zona binding
 and/or zona free hamster oocyte assays, hyperactivated motility assessment to test the
 candidate contraceptive agents for inhibition of sperm capacitation.

## Key facts

- **NIH application ID:** 10017315
- **Project number:** 5P50HD100549-02
- **Recipient organization:** WEILL MEDICAL COLL OF CORNELL UNIV
- **Principal Investigator:** Dolores Jean Lamb
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $150,575
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017315

## Citation

> US National Institutes of Health, RePORTER application 10017315, Andrology Core (5P50HD100549-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10017315. Licensed CC0.

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