# Dominantly Inherited Alzheimer Network  Administrative Core

> **NIH NIH U19** · WASHINGTON UNIVERSITY · 2020 · $2,394,859

## Abstract

Core A: Administration PROJECT SUMMARY/ABSTRACT
Core A: Administration oversees the entire DIAN project: coordinating activities of the other Cores and
subcontractors, managing and supporting the DIAN Steering Committee, seeking and implementing feedback
from the External Advisory Committee, interacting with the NIA's scientific and administrative liaisons, and
managing financial affairs overall and with individual clinical sites. It is led by the DIAN Principal Investigator
Dr. Randall Bateman, with the assistance of Associate Directors Drs. John Morris, David Holtzman, and
Celeste Karch, and Deputy Director Laura Swisher. DIAN was designed to establish an international, multisite
collaborative study using comprehensive, intensive, uniform, standardized protocols in a rare group of
participants at risk for autosomal dominant Alzheimer's disease (ADAD). DIAN protocols harmonize imaging
and biomarker procedures with the Alzheimer's Disease Neuroimaging Initiative (ADNI) and clinical and
psychometric procedures with the National Alzheimer's Coordinating Center (NACC) to make future
comparisons with sporadic AD possible. The highly successful DIAN study now includes 20 performance sites,
including 12 international sites, 9 of which are self-funded and follow DIAN protocols, with the NIH supporting
central functions such as the Cores. The Administration Core manages the subcontracts for all performance
sites and leads communication with and between sites, monitors site performance, and conducts site training
and initiation visits for new sites.
 The Administration Core has continued to support aims of the DIAN study since its inception, including
maintaining a registry for ADAD families, recruiting and retaining participants, maintaining an extensive
database and biospecimen repository, and providing genetic counseling and testing to DIAN participants who
wish to learn their mutation status. In this renewal, the Administration Core will lead the harmonization of the
DIAN observational study (DIAN-OBS), DIAN Trials Unit (DIAN-TU), and DIAN Expanded Registry (DIAN-
EXR), including working with all Cores and performance sites to implement ICH GCP and 21 CFR Part 11
compliance. The synergy among the three DIAN studies will facilitate efficient sharing of data and resources
and increase the volume and quality of DIAN-OBS data. Additionally, the Administration Core will support the
newly established Cognition Core in integrating its directives. The Administration Core will also closely
coordinate, support and monitor the implementation of the three DIAN Scientific Projects. Through leadership,
collaboration, and extensive coordination, the Administration Core will continue to accomplish DIAN's aims and
scientific initiatives, and ensure that DIAN continues to be a cohesive, rigorous, and innovative study.

## Key facts

- **NIH application ID:** 10017823
- **Project number:** 5U19AG032438-09
- **Recipient organization:** WASHINGTON UNIVERSITY
- **Principal Investigator:** RANDALL J BATEMAN
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $2,394,859
- **Award type:** 5
- **Project period:** 2008-09-15 → 2024-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017823

## Citation

> US National Institutes of Health, RePORTER application 10017823, Dominantly Inherited Alzheimer Network  Administrative Core (5U19AG032438-09). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10017823. Licensed CC0.

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