# Administrative Core

> **NIH NIH U19** · DUKE UNIVERSITY · 2020 · $1,832,612

## Abstract

ABSTRACT – Administrative Core
The Admin Core will provide structure and oversight to enable the Alzheimer’s Gut Microbiome Project to
achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in
Alzheimer’s Disease (AD) pathogenesis. This Core is co-led by Duke’s Rima Kaddurah-Daouk, PhD, UCSD’s
Robert Knight, PhD, and UCLA’s Sarkis Mazmanian, PhD, who bring considerable leadership experience and
complementary scientific expertise to the U19. Dr. Kaddurah-Daouk will serve as contact PI, and brings
experience having successfully led four large NIH-funded consortia and is a pioneer in the application of
metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD. Dr. Knight
runs the Earth Microbiome Project and American Gut Project and developed microbiome technologies widely
used in the field. Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of
neuropsychiatric diseases. This team is uniquely qualified to lead and coordinate this large program. Three
clinical AD experts (Drs. James Brewer, Andrew Saykin, and Murali Doraiswamy) will provide oversight for all
clinical activities including samples collection for national AD research centers and flow of samples through the
National Centralized Repository for AD and Related Dementias (NCRAD) center. Through its three Aims, the
Admin Core will ensure all Projects and Cores function as an efficient, effective, and integrated whole that all
components of the U19 have access to the tools and resources necessary to do the proposed work, and that
scientific progress is rapid, rigorous, and efficient. This Core will interact with all U19 Projects and Cores
through oversight, governance, and management. Main objectives of the Admin core are the integration of data
developed by collaborators through the creation of a relational database to manage all data-related activities
as well as the creation of a repository of uniformly collected biospecimens at the NCRAD which will be made
available to collaborators as well as the greater research community. Through our discussions, this Core will
facilitate rigorous oversight of research and data interpretation. Thus this Core’s activities are critical to our
collective success.

## Key facts

- **NIH application ID:** 10017869
- **Project number:** 5U19AG063744-02
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** Rima F Kaddurah-Daouk
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,832,612
- **Award type:** 5
- **Project period:** 2019-09-15 → 2024-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017869

## Citation

> US National Institutes of Health, RePORTER application 10017869, Administrative Core (5U19AG063744-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10017869. Licensed CC0.

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