# Biofluid Core

> **NIH NIH U19** · MAYO CLINIC ROCHESTER · 2020 · $293,894

## Abstract

ABSTRACT – ARTFL LEFFTDS Longitudinal FTLD: BIOFLUID CORE
Successful treatment of Frontotemporal Lobar Degeneration (FTLD) will require early and accurate diagnosis,
and the ability to monitor the effects of novel interventions in clinical trials. An overarching goal of ALLFTD is to
generate a well-characterized population of potential clinical trial participants who have data relevant to clinical
trial inclusion and stratification criteria, for which fluid biomarker data from blood or CSF are useful. Moreover,
as increasing numbers of clinical trials for FTLD are imminent, there is an urgent need to refine current fluid
biomarkers and develop new tools with improved sensitivity and specificity to elucidate downstream effects of
interventions. In addition to generating fluid biomarker data, a major role of the Biofluid Core will be to manage
biospecimen and biomarker data sharing as well as to help manage collaborative biomarker discovery efforts
with academia and industry. The Biofluid Core will be led by experts in FTLD biomarkers, Drs. Leonard
Petrucelli and Adam Boxer, and an expert in CSF neurodegenerative biomarker discovery and analysis, Dr.
Anne Fagan, to achieve the following aims: (1) Oversee biofluid specimen collection, processing, storage and
sharing in collaboration with the Clinical Core, Administrative Core and the National Centralized Repository for
Alzheimer's Disease and Related Dementias (NCRAD) biobank. (2) Perform measurements of standard
biomarkers of neurodegeneration in CSF and blood in all participants, and targeted measurements of
genetically relevant proteins in specific f-FTLD populations. (3) Support external collaborations to identify new
FTLD therapeutic targets and biomarkers.

## Key facts

- **NIH application ID:** 10017890
- **Project number:** 5U19AG063911-02
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** ADAM L. BOXER
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $293,894
- **Award type:** 5
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017890

## Citation

> US National Institutes of Health, RePORTER application 10017890, Biofluid Core (5U19AG063911-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10017890. Licensed CC0.

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