# Core B:  Biospecimen and Pathology Core

> **NIH NIH P50** · MAYO CLINIC ROCHESTER · 2020 · $288,298

## Abstract

Project Summary/Abstract
The primary objective of the Biospecimen and Pathology Core of the Mayo Clinic Breast Cancer SPORE is to
provide an effective centralized resource that will accrue clinically derived breast tissue samples and
characterize them for standard clinical pathological parameters (e.g., stage, biomarker status, diagnosis) in
order to create banks and cohorts for research purposes. Samples collected will include fresh frozen and
formalin fixed paraffin embedded cancers, benign breast disease tissues, and “normal” mammoplasty/risk
reduction specimens, as well as whole blood. The Biospecimen and Pathology Core will also perform expert
pathological evaluation of research related histopathological parameters (e.g., atypia in benign breast disease
and subclassification of TN tumors) and interpretation of immunostains relevant to SPORE projects (e.g.,
ERβ). The Core will support translational studies by selecting appropriate samples for analysis, assisting with
application of special technologies to SPORE projects (e.g., image analysis), and assessing antibody
optimizations (e.g., phospho-ERβ, cystatin 1/2/4, cystatin 5, and phospho-smad2/3). Immunostain
quantification evaluation using digitized image analysis will be developed and standardized by the CORE. The
Biospecimen and Pathology Core will coordinate with the Mayo Biospecimen Accessioning and Processing
Shared Resource to store cryospecimens and to process blood samples to provide genomic DNA and serum
aliquots; it will collaborate with the Mayo Pathology Research Shared Resource to provide histology and other
tissue-based services, including paraffin and frozen sectioning, immunohistochemistry, tissue microarray
construction, and digital imaging. Working closely with existing infrastructure such as these shared resources
minimizes redundancy of services and utilizes existing experience and state of the art equipment.

## Key facts

- **NIH application ID:** 10017902
- **Project number:** 5P50CA116201-15
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** Daniel Visscher
- **Activity code:** P50 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $288,298
- **Award type:** 5
- **Project period:** 2005-09-22 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10017902

## Citation

> US National Institutes of Health, RePORTER application 10017902, Core B:  Biospecimen and Pathology Core (5P50CA116201-15). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10017902. Licensed CC0.

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