# SPIRRIT-HFPEF - CCC

> **NIH NIH U01** · DUKE UNIVERSITY · 2020 · $1,660,451

## Abstract

Spironolactone Initiation Registry Randomized Interventional Trial in Heart Failure with Preserved
Ejection Fraction (SPIRRIT-HFpEF) is a pragmatic, registry-based randomized clinical trial that proposes to
evaluate the clinical effectiveness of spironolactone versus usual care. The primary hypothesis of SPIRRIT-
HFpEF is that treatment with spironolactone will reduce cardiovascular mortality compared with usual care.

## Key facts

- **NIH application ID:** 10018073
- **Project number:** 5U01HL134679-04
- **Recipient organization:** DUKE UNIVERSITY
- **Principal Investigator:** ADAM D DEVORE
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,660,451
- **Award type:** 5
- **Project period:** 2017-09-15 → 2022-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10018073

## Citation

> US National Institutes of Health, RePORTER application 10018073, SPIRRIT-HFPEF - CCC (5U01HL134679-04). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10018073. Licensed CC0.

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